Gut Commensal Barnesiella Intestinihominis Ameliorates Hyperglycemia and Liver Metabolic Disorders

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2024-12-31 DOI:10.1002/advs.202411181

Ye Zhang, Dong Xu, Xuyi Cai, Xue Xing, Xin Shao, Ailing Yin, Yanyan Zhao, Mengyuan Wang, Yu-nuo Fan, Boao Liu, Hua Yang, Wei Zhou, Ping Li

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Abstract

Recent studies have highlighted the role of the gut microbiota in type 2 diabetes (T2D). Improving gut microbiota dysbiosis can be a potential strategy for the prevention and management of T2D. Here, this work finds that the abundance of Barnesiella intestinihominis is significantly decreased in the fecal of T2D patients from 2-independent centers. Oral treatment of live B. intestinihominis (LBI) considerably ameliorates hyperglycemia and liver metabolic disorders in HFD/STZ-induced T2D models and db/db mice. LBI-derived acetate has similar protective effects against T2D. Mechanistically, acetate enhances fibroblast growth factor 21 (FGF21) through inhibition of histone deacetylase 9 (HDAC9) to increase H3K27 acetylation at the FGF21 promoter. The screening puerarin from Gegen Qinlian decoction in a gut microbiota-dependent manner improved hyperglycemia and liver metabolic disorders by promoting the growth of B. intestinihominis. This study suggests that gut commensal B. intestinihominis and puerarin, respectively have the potential as a probiotic and prebiotic in the treatment of T2D.

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肠道共生巴氏菌改善高血糖和肝脏代谢紊乱。

最近的研究强调了肠道微生物群在2型糖尿病（T2D）中的作用。改善肠道菌群失调可能是预防和管理T2D的潜在策略。本研究发现，来自2个独立中心的T2D患者粪便中的Barnesiella untestinihominis丰度显著降低。口服活B. testinihominis （LBI）可显著改善HFD/ stz诱导的T2D模型和db/db小鼠的高血糖和肝脏代谢紊乱。lbi衍生的醋酸酯对T2D具有类似的保护作用。从机制上说，醋酸酯通过抑制组蛋白去乙酰化酶9 （HDAC9）来增强成纤维细胞生长因子21 (FGF21)，从而增加FGF21启动子上H3K27的乙酰化。从葛根芩连汤中筛选葛根素，以肠道菌群依赖的方式促进肠芽胞杆菌生长，改善高血糖和肝脏代谢紊乱。本研究提示肠道共生菌b.n untesinihominis和葛根素分别具有作为治疗T2D的益生菌和益生元的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.