Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-01-02 DOI:10.1038/s41590-024-02039-w

Chad A. Brambley, Brian M. Baker

引用次数: 0

Abstract

A healthy immune system is tolerant to self-antigens while maintaining responsiveness to foreign threats. Co-expression of the inhibitory receptors PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4+ T cells independently of thymic selection.

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外周血CD4+ T细胞的免疫耐受受PD-1和CD73的协同调节

健康的免疫系统既能耐受自身抗原，又能对外来威胁保持反应能力。抑制受体PD-1和CD73的共表达通过限制自身反应性CD4+ T细胞的扩增而独立于胸腺选择来调节耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.