Past interactions of T cells with antigens shape CAR T cell responses

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-01-02 DOI:10.1038/s41590-024-02048-9

引用次数: 0

Abstract

CAR T cells are engineered from a heterogeneous pool of T cells. This study shows that CAR T cells are epigenetically imprinted by the previous antigen exposure of the original T cell, which affects subsequent functional characteristics. These epigenetic differences can be used to identify genes that can be manipulated to modify function.

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过去T细胞与抗原的相互作用形成CAR - T细胞反应

CAR - T细胞是由异质的T细胞池改造而成的。这项研究表明，CAR - T细胞受到原始T细胞先前抗原暴露的表观遗传印记，影响随后的功能特征。这些表观遗传差异可以用来识别可以被操纵来改变功能的基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.