Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-01-02 DOI:10.1016/j.stem.2024.12.001

Soniya Tamhankar, Eric V. Shusta, Sean P. Palecek

引用次数: 0

Abstract

Tissue-engineered vascular conduits (TEVCs) are a promising blood vessel replacement. In a recent publication in Cell Stem Cell,¹ Park et al. developed TEVCs comprised of decellularized human umbilical arteries lined with shear-trained, human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) that resisted thrombosis and exhibited patency upon grafting into the rat inferior vena cava (IVC).

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工程hipsc衍生血管移植物为无血栓形成的血管治疗带来希望

组织工程血管导管（tevc）是一种很有前途的血管替代品。在《细胞干细胞》（Cell Stem Cell）杂志最近发表的一篇文章中，1 Park等人开发了tevc，该tevc由去细胞化的人脐动脉组成，内衬剪切训练的人诱导多能干细胞（hiPSC）来源的内皮细胞（ECs），这些内皮细胞在移植到大鼠下腔静脉（IVC）后可抵抗血栓形成并显示通畅。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.