Slide-Ring Structured Stress-Electric Coupling Hydrogel Microspheres for Low-Loss Transduction Between Tissues

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Fan Wang, Xiaoyu Han, Zeyu Han, Juan Wang, Zhengwei Cai, Gang Chen, Dingqun Bai, Wenguo Cui
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Abstract

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane and conductive polypyrrole to construct stress-electric coupling hydrogel microspheres. The molecular slippage mechanism of slide-ring structure stores and releases mechanical energy, reducing mechanical loss, the piezoelectric barium titanate enables stress-electricity conversion, and conjugated π-electron movement in conductive network improves the internal electron transfer efficiency of microspheres, thereby reducing the loss in stress-electricity conversion for the first time. Compared to traditional piezoelectric hydrogel microspheres, the stress-electric coupling efficiency of low-dissipation microspheres increased by 2.3 times, and the energy dissipation decreased to 43%. At cellular level, electrical signals generated by the microspheres triggered Ca2+ influx into stem cells and upregulated the cAMP signaling pathways, promoting chondrogenic differentiation. Enhanced electrical signals induced macrophage polarization to the M2 phenotype, reshaping inflammation and promoting tissue repair. In vivo, the low-dissipation microspheres restored low-loss transduction between tissues, alleviated cartilage damage, improved behavioral outcomes, and promoted the treatment of osteoarthritis in rats. Therefore, this study proposes a new strategy for restoring low-loss transduction between tissues, particularly in mechanically sensitive tissues.

Abstract Image

Abstract Image

用于组织间低损耗转导的滑环结构应力-电偶联水凝胶微球
组织损伤部位的高转导损失阻碍了修复。压电生物材料的高耗散特性对其机电转换提出了挑战。因此,利用超分子工程和微流体技术,引入滑环聚轮烷和导电聚吡咯构建应力-电偶联水凝胶微球。滑环结构的分子滑移机制储存和释放机械能,减少机械损失,压电钛酸钡实现应力-电转换,导电网络中共轭π-电子运动提高了微球内部电子传递效率,从而首次降低了应力-电转换的损失。与传统压电水凝胶微球相比,低耗散微球的应力-电耦合效率提高了2.3倍,能量耗散降至43%。在细胞水平上,微球产生的电信号触发Ca2+内流进入干细胞,上调cAMP信号通路,促进软骨分化。增强的电信号诱导巨噬细胞向M2表型极化,重塑炎症,促进组织修复。在体内,低耗散微球恢复了组织间的低损耗转导,减轻了软骨损伤,改善了行为结果,促进了骨关节炎的治疗。因此,本研究提出了一种恢复组织间低损失转导的新策略,特别是在机械敏感组织中。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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