The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-12-25 DOI:10.1016/j.archger.2024.105731

Ali Nejatian Hoseinpour , Minoo Bassami , Sajad Ahmadizad , Lars Donath , Shayan Setayesh , Meraj Mirzaei , Gholam Rasul Mohammad Rahimi

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引用次数: 0

Abstract

Background

: Older adults experience chronic inflammation, which is associated with health conditions such as sarcopenia, and resulting in reduced functional capacity. Resistance training (RT) is a beneficial intervention for improving health in the elderly.

Objective

: This study aimed to investigate the effect of RT on inflammatory biomarkers, body composition, and functional capacity in healthy adults aged 60 years and over. Additionally, this study conducted a meta-regression to investigate the moderating effect of exercise variables on inflammatory markers.

Method

: Medline, PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar were searched systematically until December 2023. Randomized controlled trials (RCTs) assessing the impact of RT on C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), body weight, BMI, fat percentage, fat mass, lean mass, leg extension strength and six-minute walk test (6-MWT) were included. Effect size was estimated by using the mean difference (MD) with 95 % confidence interval (CI).

Results

: Nineteen RTCs involving 728 participants were included. The results revealed that CRP levels significantly decreased following RT programs (MD:0.74, p = 0.008), while TNF-α (MD: 0.1, p = 0.95) and IL-6 (MD:0.27, p = 0.12) did not show significant changes. Additionally, RT enhanced leg extension strength and 6-MWT performance.

Conclusion

: RT effectively reduces CRP concentrations and enhances functional capacity in healthy older adults. However, it does not have a significant impact on TNF-α and IL-6 levels. Future researches are needed to make a clear conclusion and understand the mechanisms underlying the effects of RT in healthy older adults.

Registration: The original protocol was registered (CRD42023487573) in PROSPERO database.

查看原文本刊更多论文

抗阻训练对健康老年人炎症标志物、身体成分和功能能力的影响：一项系统回顾和荟萃分析

背景：老年人经历慢性炎症，这与肌肉减少症等健康状况有关，并导致功能下降。抗阻训练是改善老年人健康状况的一种有益干预手段。目的：本研究旨在探讨RT对60岁及以上健康成人炎症生物标志物、身体成分和功能能力的影响。此外，本研究还进行了meta回归研究运动变量对炎症标志物的调节作用。方法：系统检索Medline、PubMed、Web of Science、Cochrane Library、Embase、谷歌Scholar，检索截止至2023年12月。纳入评估RT对c反应蛋白（CRP）、白细胞介素-6 （IL-6）和肿瘤坏死因子-α (TNF-α)、体重、BMI、脂肪百分比、脂肪质量、瘦质量、腿部伸展力量和6分钟步行测试（6-MWT）影响的随机对照试验（rct）。效应量采用95%置信区间（CI）的均值差（MD）估计。结果：共纳入19个rtc，共728名受试者。结果显示，放疗后CRP水平显著降低（MD:0.74, p= 0.008），而TNF-α (MD: 0.1, p= 0.95)和IL-6 （MD:0.27, p= 0.12）无显著变化。此外，RT增强了腿部伸展力量和6-MWT性能。结论：RT可有效降低健康老年人CRP浓度，增强功能。但对TNF-α和IL-6水平无明显影响。未来的研究需要得出明确的结论，并了解RT在健康老年人中的作用机制。注册：在PROSPERO数据库中注册原始协议（CRD42023487573）。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.