Lean body weight-based contrast injection protocol in liver CT: optimization of contrast medium dose.

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiologia Medica Pub Date : 2024-12-30 DOI:10.1007/s11547-024-01944-2

Damiano Caruso, Domenico De Santis, Antonella Del Gaudio, Daniela Valanzuolo, Dominga Pugliese, Marta Zerunian, Michela Polici, Giuseppe Tremamunno, Benedetta Masci, Andrea Laghi

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引用次数: 0

Abstract

Objectives: To evaluate liver enhancement and image quality of abdominal CECT examinations acquired with multiple LBW-based contrast medium injection protocols.

Material & methods: One hundred fifty patients who underwent a clinically indicated CECT examination were prospectively and randomly assigned to one of the following contrast medium injection protocol groups: A, 700 mg iodine(I)/kg of LBW; B, 650 mgI/kg of LBW; and C, 600 mgI/kg of LBW. Liver signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and magnitude of contrast enhancement (ΔHU) were calculated. Subjective image quality was assessed with 5-point Likert scale.

Results: The final population included 145 patients (64 females), with 50, 48, and 47 in group A, B, and C, respectively. Group A showed significantly higher SNR, CNR and ΔHU than group B (p = .018, p = .004, and p = .031, respectively) and group C (p = .024, p = .043, and p = .004). Group B had similar SNR, CNR, and ΔHU to group C (all p = 1). ΔHU was < 50 HU in 2, 7, and 11 patients in group A (48.2 ± 0.1), B (43.7 ± 5), and C (44.4 ± 5), respectively. Group A achieved the highest scores in terms of overall image quality, artifacts, and diagnostic confidence (both scores: 4; IQRs: 4-5) compared to group B (both scores: 3; IQRs: 3-5; p ≥ .037) and group C (overall image quality score: 3; IQR: 2-5; p = .011. Artifact and diagnostic confidence score: 3; IQR: 1-4; p ≥ .009).

Conclusions: A dosage of 700 mgI/kg of LBW yields optimal liver enhancement and grants higher image quality compared to lower contrast medium dosages.

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基于瘦体重的肝CT造影剂注射方案：造影剂剂量的优化。

目的：评价多种基于lbw的造影剂注射方案所获得的腹部CECT肝脏增强和图像质量。材料与方法：150例接受临床指征CECT检查的患者前瞻性随机分配到以下对比剂注射方案组：a， 700 mg碘(I)/kg LBW；B, 650 mgI/kg LBW；C为600 mgI/kg LBW。计算肝脏信噪比（SNR）、对比噪声比（CNR）和对比度增强幅度（ΔHU）。主观图像质量采用李克特5分制评价。结果：最终纳入145例患者（女性64例），A、B、C组分别为50例、48例、47例。A组的SNR、CNR和ΔHU均显著高于B组(p =。018, p =。004, p =。031)和C组(p =。024, p =。043, p = .004)。B组SNR、CNR、ΔHU与C组相似（均p = 1）。结论：与较低造影剂剂量相比，700 mgI/kg的LBW剂量可产生最佳的肝脏增强效果，并获得更高的图像质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.