Approaching Universal Prenatal Detection of Significant Cardiovascular Malformations in Nevada.

IF 2.7 2区医学 Q2 GENETICS & HEREDITY

Prenatal Diagnosis Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI:10.1002/pd.6739

William N Evans, Ruben J Acherman, Katrinka T Kip, Carlos F Luna, Joseph M Ludwick, Robert C Rollins, William J Castillo, John A Alexander, Tina W Kwan, Shilpi Garg, Humberto Restrepo

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引用次数: 0

Abstract

Objective: To report our recent experience with prenatal detection of significant cardiovascular malformations (CVMs) in Nevada's state-wide maternal population receiving prenatal care.

Methods: We queried our databases for those with significant CVMs diagnosed pre- or postnatally between May 1, 2021, and April 30, 2024. We defined CVMs as those that required, would have required, or will likely require a therapeutic procedure in the first 12 months. Additionally, we included those with atrioventricular and ventriculoarterial discordance and left isomeric situs, both unaccompanied by additional CVMs, and congenital complete heart block. We defined routine prenatal care as obstetric care, which included at least one fetal anatomical survey ultrasound.

Results: We identified 390 cases of significant CVMs. Of the 390 cases, 359 (92%) had prenatal care over the three-year observation period, with prenatal detection rates for the three 12-month intervals: 76% (87/115), 87% (94/108), and 95% (129/136) respectively (p < 0.001 by chi-square). A total of 310 prenatal diagnoses were made from comprehensive fetal echocardiograms performed on 8397 pregnant women at maternal-fetal-medicine centers.

Conclusion: To our knowledge, these results represent the highest prenatal detection rate for significant CVMs, in a state-wide maternal population in the United States.

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接近普遍产前检测显著心血管畸形在内华达州。

目的：报告我们最近的经验产前检测显著心血管畸形（cvm）在内华达州全州孕产妇人口接受产前护理。方法：我们查询了2021年5月1日至2024年4月30日期间产前或产后诊断的显著cvm的数据库。我们将cvm定义为需要、曾经需要或可能需要在前12个月内进行治疗的患者。此外，我们还纳入了那些伴有房室和室动脉不一致和左异构体位置的患者，这两种患者均未伴有额外的cvm和先天性完全性心脏传导阻滞。我们将常规产前护理定义为产科护理，其中包括至少一次胎儿解剖超声检查。结果：我们确定了390例显著cvm。390例中，359例（92%）在三年观察期内接受了产前护理，三个12个月间隔的产前检出率分别为76%（87/115）、87%（94/108）和95%（129/136）。(p)结论：据我们所知，这些结果代表了美国全州孕产妇人群中显著cvm的最高产前检出率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prenatal Diagnosis 医学-妇产科学

CiteScore

5.80

自引率

13.30%

发文量

204

审稿时长

2 months

期刊介绍： Prenatal Diagnosis welcomes submissions in all aspects of prenatal diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing: all aspects of fetal imaging, including sonography and magnetic resonance imaging; prenatal cytogenetics, including molecular studies and array CGH; prenatal screening studies; fetal cells and cell-free nucleic acids in maternal blood and other fluids; preimplantation genetic diagnosis (PGD); prenatal diagnosis of single gene disorders, including metabolic disorders; fetal therapy; fetal and placental development and pathology; development and evaluation of laboratory services for prenatal diagnosis; psychosocial, legal, ethical and economic aspects of prenatal diagnosis; prenatal genetic counseling