Human Papilloma Virus Infection and Sinonasal Inverted Papilloma Recurrence: A Meta-Analysis.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-04-01 Epub Date: 2024-12-31 DOI:10.1002/ohn.1108

Fayssal Alqudrah, Sharwani Kota, Jason Morgan, Phillip R Purnell, Justin P McCormick

{"title":"Human Papilloma Virus Infection and Sinonasal Inverted Papilloma Recurrence: A Meta-Analysis.","authors":"Fayssal Alqudrah, Sharwani Kota, Jason Morgan, Phillip R Purnell, Justin P McCormick","doi":"10.1002/ohn.1108","DOIUrl":null,"url":null,"abstract":"Objective: Prior studies have been contradictory on the role of human papillomavirus (HPV) infection in sinonasal inverted papilloma (SNIP) recurrence. This systematic review and meta-analysis was performed to further evaluate this potential association.Data sources: PubMed, Embase, and Scopus electronic databases.Review methods: Case-control studies reporting SNIP recurrence data and HPV status identified by polymerase chain reaction (PCR) and in-situ hybridization (ISH). Meta-analysis was performed to determine pooled odds ratios (ORs) and 95% confidence intervals (CI).Results: 25 studies were identified including a total of 1116 benign SNIP tumors. A total of 267 SNIP were HPV+, 103 of which were recurrent, and 849 SNIP were HPV-, with 231 being recurrent. The pooled standard OR for recurrence in HPV+ tumors was 2.05 (95% CI: 1.31-3.19). Stratification by low-risk and high-risk HPV subtypes were not statistically significant. The standard OR for SNIP recurrence in low-risk and high-risk HPV+ subtypes were 1.57 (95% CI: 0.98-2.54) and 1.67 (95% CI: 0.98-2.80), respectively.Conclusion: Infection with HPV may be associated with an increased risk of SNIP recurrence. This increased risk seems to be independent of HPV subtype based on low-risk or high-risk status. However, this correlation was variable among recently published studies requiring additional investigation.","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":"1155-1163"},"PeriodicalIF":2.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947860/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Otolaryngology- Head and Neck Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ohn.1108","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Prior studies have been contradictory on the role of human papillomavirus (HPV) infection in sinonasal inverted papilloma (SNIP) recurrence. This systematic review and meta-analysis was performed to further evaluate this potential association.

Data sources: PubMed, Embase, and Scopus electronic databases.

Review methods: Case-control studies reporting SNIP recurrence data and HPV status identified by polymerase chain reaction (PCR) and in-situ hybridization (ISH). Meta-analysis was performed to determine pooled odds ratios (ORs) and 95% confidence intervals (CI).

Results: 25 studies were identified including a total of 1116 benign SNIP tumors. A total of 267 SNIP were HPV+, 103 of which were recurrent, and 849 SNIP were HPV-, with 231 being recurrent. The pooled standard OR for recurrence in HPV+ tumors was 2.05 (95% CI: 1.31-3.19). Stratification by low-risk and high-risk HPV subtypes were not statistically significant. The standard OR for SNIP recurrence in low-risk and high-risk HPV+ subtypes were 1.57 (95% CI: 0.98-2.54) and 1.67 (95% CI: 0.98-2.80), respectively.

Conclusion: Infection with HPV may be associated with an increased risk of SNIP recurrence. This increased risk seems to be independent of HPV subtype based on low-risk or high-risk status. However, this correlation was variable among recently published studies requiring additional investigation.

查看原文本刊更多论文

人乳头瘤病毒感染与鼻窦内翻性乳头瘤复发：荟萃分析。

目的：关于人乳头瘤病毒（HPV）感染在鼻窦内翻性乳头瘤（SNIP）复发中的作用，以往的研究存在矛盾。本研究进行了系统回顾和荟萃分析，以进一步评估这种潜在的关联。数据来源：PubMed、Embase和Scopus电子数据库。回顾方法：病例对照研究报告SNIP复发数据和HPV状态通过聚合酶链反应（PCR）和原位杂交（ISH）鉴定。进行荟萃分析以确定合并优势比（ORs）和95%置信区间（CI）。结果：共鉴定25例，其中良性SNIP肿瘤1116例。267例为HPV+型，其中103例复发；849例为HPV-型，其中231例复发。HPV+肿瘤复发的合并标准OR为2.05 （95% CI: 1.31-3.19）。低危和高危HPV亚型的分层无统计学意义。低危和高危HPV+亚型SNIP复发的标准OR分别为1.57 （95% CI: 0.98-2.54）和1.67 （95% CI: 0.98-2.80）。结论：HPV感染可能与SNIP复发风险增加有关。这种增加的风险似乎与基于低风险或高风险状态的HPV亚型无关。然而，在最近发表的需要进一步调查的研究中，这种相关性是可变的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.