RNA Modifications and Their Role in Regulating KSHV Replication and Pathogenic Mechanisms.

IF 6.8 3区 医学 Q1 VIROLOGY
S Schultz, K Gomard-Henshaw, M Muller
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引用次数: 0

Abstract

Kaposi's sarcoma-associated herpesvirus is an oncogenic gammaherpesvirus that plays a major role in several human malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The complexity of KSHV biology is reflected in the sophisticated regulation of its biphasic life cycle, consisting of a quiescent latent phase and virion-producing lytic replication. KSHV expresses coding and noncoding RNAs, including microRNAs and long noncoding RNAs, which play crucial roles in modulating viral gene expression, immune evasion, and intercellular communication. Recent studies have highlighted the importance of RNA modifications, also known as the epitranscriptome, in regulating KSHV-encoded RNAs, adding a novel layer of posttranscriptional control previously unknown. These RNA modifications, such as N6-methyladenosine, A-to-I editing, and N4-acetylcytidine, are involved in fine-tuning KSHV gene expression during both latency and lytic replication. Understanding the role of RNA modifications in KSHV infection is essential for revealing new regulatory mechanisms and identifying therapeutic opportunities. Targeting these RNA modifications could serve as a strategy to disrupt key viral processes, offering promising insights into KSHV pathogenesis and therapeutic interventions.

RNA修饰及其在KSHV复制调控中的作用和致病机制
卡波西氏肉瘤相关疱疹病毒是一种致癌的伽玛疱疹病毒,在几种人类恶性肿瘤中起主要作用,包括卡波西氏肉瘤、原发性积液性淋巴瘤和多中心Castleman病。KSHV生物学的复杂性反映在其两期生命周期的复杂调控上,两期生命周期包括一个静止的潜伏期和产生病毒粒子的裂解复制。KSHV表达编码和非编码rna,包括microrna和长链非编码rna,它们在调节病毒基因表达、免疫逃避和细胞间通讯中起着至关重要的作用。最近的研究强调了RNA修饰(也称为外转录组)在调节kshv编码RNA中的重要性,增加了一层以前未知的转录后控制。这些RNA修饰,如n6 -甲基腺苷、A-to-I编辑和n4 -乙酰胞苷,在潜伏期和裂解复制期间都参与微调KSHV基因表达。了解RNA修饰在KSHV感染中的作用对于揭示新的调控机制和确定治疗机会至关重要。靶向这些RNA修饰可以作为破坏关键病毒过程的策略,为KSHV的发病机制和治疗干预提供有希望的见解。
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来源期刊
Journal of Medical Virology
Journal of Medical Virology 医学-病毒学
CiteScore
23.20
自引率
2.40%
发文量
777
审稿时长
1 months
期刊介绍: The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.
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