Biocompatibility of Novel Marine Collagen on Periodontal Ligament Fibroblasts: A Pathway to Enhanced Regenerative Therapies.

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2025-01-01 DOI:10.1002/cbf.70040

Yasir Dilshad Siddiqui, Erry Mochamad Arief, Muhammad Aliyan Saddique

引用次数: 0

Abstract

Body wall of sea cucumber Bohadschia bivittate contains a protein consisting of highly insoluble collagen fibers. We aimed to evaluate the biocompatibility and cytotoxicity of nonirradiated or γ-irradiated pepsin soluble collagen (PSC) extracted from Bohadschia bivittata on human periodontal ligament fibroblasts cells. The MTT assay showed significant increase in the cell viability values indicating that PSC is noncytotoxic. Further, nonirradiated PSC showed higher cell viabilities values than γ-irradiated PSC at all concentration, especially at an optimal dilution of 25% (p < 0.05). This exploratory study suggests that PSC from Bohadschia bivittata could be utilized as a novel biomaterial in periodontal regenerative therapies.

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新型海洋胶原在牙周韧带成纤维细胞上的生物相容性：增强再生治疗的途径。

海参体壁含有一种由高度不溶性胶原纤维组成的蛋白质。本研究旨在评价双斑波氏菌胃蛋白酶可溶性胶原蛋白（PSC）对人牙周韧带成纤维细胞的生物相容性和细胞毒性。MTT试验显示细胞活力值显著增加，表明PSC无细胞毒性。此外，在所有浓度下，未辐照的PSC都比γ辐照的PSC显示出更高的细胞活力值，特别是在25%的最佳稀释度(p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.