Harnessing Microbial Signal Transduction Systems in Natural and Synthetic Consortia for Biotechnological Applications.

IF 3.2 4区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ahmadullah Zahir, Peter A Okorie, Veronica N Nwobasi, Esther I David, Rita O Nwankwegu, Fidelis Azi
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引用次数: 0

Abstract

Signal transduction is crucial for communication and cellular response in microbial communities. Consortia rely on it for effective communication, responding to changing environmental conditions, establishing community structures, and performing collective behaviors. Microbial signal transduction can be through quorum sensing (QS), two-component signal transduction systems, biofilm formation, nutrient sensing, chemotaxis, horizontal gene transfer stress response, and so forth. The consortium uses small signaling molecules in QS to regulate gene expression and coordinate intercellular communication and behaviors. Biofilm formation allows cells to adhere and aggregate, promoting species interactions and environmental stress resistance. Chemotaxis enables directional movement toward or away from chemical gradients, promoting efficient resource utilization and community organization within the consortium. In recent years, synthetic microbial consortia have gained attention for their potential applications in biotechnology and bioremediation. Understanding signal transduction in natural and synthetic microbial consortia is important for gaining insights into community dynamics, evolution, and ecological function. It can provide strategies for biotechnological innovation for enhancing biosensors, biodegradation, bioenergy efficiency, and waste reduction. This review provides compelling insight that will advance our understanding of microbial signal transduction dynamics and its role in orchestrating microbial interactions, which facilitate coordination, cooperation, gene expression, resource allocation, and trigger specific responses that determine community success.

利用微生物信号转导系统在自然和合成联合体的生物技术应用。
信号转导对微生物群落的通讯和细胞反应至关重要。联盟依靠它进行有效的沟通,响应不断变化的环境条件,建立社区结构和执行集体行为。微生物信号转导可通过群体感应(quorum sensing, QS)、双组分信号转导系统、生物膜形成、养分感应、趋化性、水平基因转移胁迫响应等途径进行。该联盟利用QS中的小信号分子调节基因表达,协调细胞间的通讯和行为。生物膜的形成使细胞粘附和聚集,促进物种相互作用和环境胁迫抗性。趋化性使生物向或远离化学梯度方向移动,促进有效的资源利用和群落组织。近年来,合成微生物群落因其在生物技术和生物修复中的潜在应用而受到人们的关注。了解天然和合成微生物群落的信号转导对于深入了解群落动态、进化和生态功能非常重要。它可以为生物技术创新提供战略,以增强生物传感器、生物降解、生物能源效率和减少废物。这篇综述提供了令人信服的见解,将推进我们对微生物信号转导动力学及其在协调微生物相互作用中的作用的理解,这些相互作用促进了协调、合作、基因表达、资源分配,并引发了决定社区成功的特定反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biotechnology and applied biochemistry
Biotechnology and applied biochemistry 工程技术-生化与分子生物学
CiteScore
6.00
自引率
7.10%
发文量
117
审稿时长
3 months
期刊介绍: Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of high quality, significant research at the interface between life sciences and their technological exploitation. The Editors will consider papers for publication based on their novelty and impact as well as their contribution to the advancement of medical biotechnology and industrial biotechnology, covering cutting-edge research in synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology.
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