Does Asthma Affect the Risk of Developing Breast Cancer?

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-01-01 DOI:10.1002/cam4.70539

Karin B Michels, Orianne Dumas, Raphaelle Varraso, Carlos A Camargo

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Abstract

Background: The role of the immune system in cancer defense is likely underappreciated. While there has been longstanding interest in the role of atopic diseases in cancer, only a few studies have tested this hypothesis.

Methods: We analyzed data from 202,055 women participating in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II) to explore whether asthma is associated with breast cancer. We used Cox proportional hazards models to link physician-diagnosed asthma with subsequent incidence of breast cancer.

Results: Across the two cohorts, we identified 18,403 cases of physician-diagnosed asthma. During 4,393,760 person-years of follow-up, 11,096 incident cases of breast cancer were diagnosed. In NHS, women with asthma had a covariate-adjusted hazard ratio of 0.92 (95% CI: 0.86-0.99) to develop breast cancer compared to women without asthma; the respective HR in NHS II was 0.93 (0.84-1.03), and 0.92 (0.87-0.98) in the pooled analysis. Among never-smokers, the HR for breast cancer was 0.91 (0.81-1.02) in NHS, 0.81 (0.70-0.93) in NHS II, and 0.86 (0.77-0.97) combined. In two large prospective cohorts of women, participants with asthma had a somewhat lower risk of breast cancer. An active immune system may provide protection from breast cancer.

Conclusions: In these longitudinal studies, women with asthma had a somewhat lower risk of breast cancer. This association was most pronounced among never smokers. An active immune system may provide protection from breast cancer.

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哮喘会影响患乳腺癌的风险吗？

背景：免疫系统在癌症防御中的作用可能被低估了。长期以来，人们一直对特应性疾病在癌症中的作用感兴趣，但只有少数研究证实了这一假设。方法：我们分析了参加护士健康研究（NHS）和护士健康研究II （NHS II）的202,055名妇女的数据，以探讨哮喘是否与乳腺癌相关。我们使用Cox比例风险模型将医生诊断的哮喘与随后的乳腺癌发病率联系起来。结果：在两个队列中，我们确定了18403例医生诊断的哮喘病例。在4,393,760人年的随访中，诊断出11,096例乳腺癌病例。在NHS中，与没有哮喘的女性相比，哮喘女性患乳腺癌的协变量校正风险比为0.92 (95% CI: 0.86-0.99)；合并分析的HR分别为0.93（0.84-1.03）和0.92（0.87-0.98）。在不吸烟者中，NHS的乳腺癌风险比为0.91 (0.81-1.02)，NHS II的风险比为0.81 (0.70-0.93)，NHS II的风险比为0.86（0.77-0.97）。在两个大型前瞻性女性队列中，患有哮喘的参与者患乳腺癌的风险略低。活跃的免疫系统可以预防乳腺癌。结论：在这些纵向研究中，患有哮喘的女性患乳腺癌的风险较低。这种关联在从不吸烟的人群中最为明显。活跃的免疫系统可以预防乳腺癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.