Cortical VIP neurons as a critical node for dopamine actions

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-01-01 DOI:10.1126/sciadv.adn3221

Jung Won Bae, Jee Hyun Yi, Seo Yeon Choe, Yulong Li, Min Whan Jung

{"title":"Cortical VIP neurons as a critical node for dopamine actions","authors":"Jung Won Bae, Jee Hyun Yi, Seo Yeon Choe, Yulong Li, Min Whan Jung","doi":"10.1126/sciadv.adn3221","DOIUrl":null,"url":null,"abstract":"<div >Dopamine modulates a wide range of cognitive processes in the prefrontal cortex, but the underlying mechanisms remain unclear. Here, we examined the roles of prefrontal vasoactive intestinal polypeptide (VIP)–expressing neurons and their D1 receptors (D1Rs) in working memory using a delayed match-to-sample task in mice. VIP neurons conveyed robust working-memory signals, and their inactivation impaired behavioral performance. Moreover, selective knockdown of D1Rs in VIP neurons also resulted in impaired performance, indicating the critical role of VIP neurons and their D1Rs in supporting working memory. Additionally, we found that dopamine release dynamics during the delay period varied depending on the target location. Furthermore, dopaminergic terminal stimulation induced a contralateral response bias and enhanced neuronal target selectivity in a laterality-dependent manner. These results suggest that prefrontal dopamine modulates behavioral responses and delay-period activity based on laterality. Overall, these findings shed light on dopamine-modulated prefrontal neural processes underlying higher-order cognitive functions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 1","pages":""},"PeriodicalIF":12.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adn3221","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Advances","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/sciadv.adn3221","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Dopamine modulates a wide range of cognitive processes in the prefrontal cortex, but the underlying mechanisms remain unclear. Here, we examined the roles of prefrontal vasoactive intestinal polypeptide (VIP)–expressing neurons and their D1 receptors (D1Rs) in working memory using a delayed match-to-sample task in mice. VIP neurons conveyed robust working-memory signals, and their inactivation impaired behavioral performance. Moreover, selective knockdown of D1Rs in VIP neurons also resulted in impaired performance, indicating the critical role of VIP neurons and their D1Rs in supporting working memory. Additionally, we found that dopamine release dynamics during the delay period varied depending on the target location. Furthermore, dopaminergic terminal stimulation induced a contralateral response bias and enhanced neuronal target selectivity in a laterality-dependent manner. These results suggest that prefrontal dopamine modulates behavioral responses and delay-period activity based on laterality. Overall, these findings shed light on dopamine-modulated prefrontal neural processes underlying higher-order cognitive functions.

Abstract Image

查看原文本刊更多论文

皮层VIP神经元是多巴胺活动的关键节点

多巴胺调节前额叶皮层广泛的认知过程，但其潜在机制尚不清楚。在这里，我们研究了前额叶血管活性肠多肽（VIP）表达神经元及其D1受体（D1Rs）在小鼠工作记忆中的作用。VIP神经元传递了强大的工作记忆信号，它们的失活损害了行为表现。此外，VIP神经元中D1Rs的选择性敲低也会导致表现受损，这表明VIP神经元及其D1Rs在支持工作记忆中的关键作用。此外，我们发现延迟期多巴胺释放动态随目标位置的不同而变化。此外，多巴胺能末端刺激诱导了对侧反应偏倚，并以侧向依赖的方式增强了神经元的靶标选择性。这些结果表明，前额叶多巴胺调节基于侧性的行为反应和延迟期活动。总的来说，这些发现揭示了多巴胺调节的前额叶神经过程是高阶认知功能的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.