Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-11-10 DOI:10.1016/j.ncrna.2024.11.001

Md. Sohanur Rahman , Suvankar Ghorai , Kingshuk Panda , Maria J. Santiago , Saurabh Aggarwal , Ting Wang , Irfan Rahman , Srinivasan Chinnapaiyan , Hoshang J. Unwalla

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引用次数: 0

Abstract

MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate gene expression by recognizing complementary sequences within messenger RNA (mRNA) molecules. Recent studies have revealed that miR-145-5p functions as a tumor suppressor in several cancers, including lung, liver, and breast cancers. Notably, miR-145-5p plays a vital role in the pathophysiology underlying HIV and chronic obstructive pulmonary diseases associated with cigarette smoke. This miRNA is abundant in biofluids and shows potential as a biomarker for the diagnosis and prognosis of several infectious diseases, such as hepatitis B, tuberculosis, and influenza. Additionally, numerous studies have indicated that other non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can regulate miR-145-5p. Given the significance of miR-145-5p, a comprehensive overview focusing on its roles in health and disease is essential. This review discusses the dual role of miR-145-5p as a protagonist and antagonist in important human diseases, with particular emphasis on disorders of the respiratory, digestive, nervous, reproductive, endocrine, and urinary systems.

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杰基尔博士还是海德先生：miR-145-5p 在人类健康和疾病中的多方面作用。

MicroRNAs （miRNAs）是一种小的非编码rna，在细胞发育、分化、生长和代谢等多种生物过程中起着至关重要的作用。mirna通过识别信使RNA （mRNA）分子中的互补序列来调节基因表达。最近的研究表明，miR-145-5p在包括肺癌、肝癌和乳腺癌在内的几种癌症中起肿瘤抑制作用。值得注意的是，miR-145-5p在与香烟烟雾相关的HIV和慢性阻塞性肺疾病的病理生理学中起着至关重要的作用。这种miRNA在生物体液中含量丰富，具有作为多种传染病（如乙型肝炎、结核病和流感）诊断和预后的生物标志物的潜力。此外，大量研究表明，其他非编码rna，包括长链非编码rna （lncRNAs）和环状rna (circRNAs)，也可以调控miR-145-5p。鉴于miR-145-5p的重要性，有必要对其在健康和疾病中的作用进行全面概述。这篇综述讨论了miR-145-5p作为主角和拮抗剂在重要人类疾病中的双重作用，特别强调呼吸、消化、神经、生殖、内分泌和泌尿系统疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.