Semantic knowledge of social norms in frontotemporal dementia patients with either predominant frontal or temporal lobe atrophy.

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2024-12-30 DOI:10.1080/23279095.2024.2447041

Ahmad Alsemari, Jason Osher, Ronald E Cobb

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引用次数: 0

Abstract

Objective: Little is known about the relative contribution of frontal and anterior temporal lobes in semantic knowledge of social norms in frontotemporal dementia (FTD). Therefore, this study examined performance of FTD patients with either frontal (F-FTD, left temporal (LT-FTD) or bitemporal lobe atrophy (BT-FTD) on the Social Norms Questionnaire (SNQ) and explored what accounts for the variance in the SNQ-break norm subscale (i.e., endorsement of inappropriate behaviors).

Methods: Using data from the National Alzheimer's Coordinating Center (NACC), groups were matched for age and education and included (a) 24 F-FTD patients, (b) 15 LT-FTD patients, (c) 17 BT-FTD patients, and (d) 188 older controls with normal cognition (NC).

Results: The BT-FTD group had significantly higher SNQ break norm score than F-FTD and NC groups with a medium effect size, which was also positively associated with the severity personality changes in the real world. Interestingly, the F-FTD and LT-FTD groups performed similarly to the NC group. Regression analysis showed that approximately 21.2% of the variance in SNQ break norms subscale score performance was explained by performance on verb naming.

Conclusions: Social inappropriateness in FTD may partially arise from a deficit in knowledge of normative behavior.

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以额叶或颞叶萎缩为主的额颞叶痴呆患者的社会规范语义知识。

目的：对额颞叶痴呆（FTD）患者的社会规范语义知识中额颞叶和前颞叶的相对贡献知之甚少。因此，本研究考察了患有额叶（F-FTD）、左颞叶（LT-FTD）或双颞叶萎缩（BT-FTD）的FTD患者在社会规范问卷（SNQ）上的表现，并探讨了SNQ-打破规范子量表（即对不当行为的认可）差异的原因。方法：使用来自国家阿尔茨海默病协调中心（NACC）的数据，各组根据年龄和教育程度进行匹配，包括(a) 24例F-FTD患者，(b) 15例LT-FTD患者，(c) 17例BT-FTD患者和(d) 188例认知正常的老年对照（NC）。结果：BT-FTD组SNQ打破规范得分显著高于F-FTD和NC组，且具有中等效应量，且与现实世界中严重人格改变呈正相关。有趣的是，F-FTD组和LT-FTD组的表现与NC组相似。回归分析表明，SNQ打破规范子量表得分表现的约21.2%的方差可以用动词命名的表现来解释。结论：FTD患者的社会不当行为可能部分源于规范行为知识的缺失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.