Associations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES

Cortex Pub Date : 2025-02-01 DOI:10.1016/j.cortex.2024.11.017

Shanshan Xiao , Natalie C. Ebner , Junhua Dang , Gull Rukh , Lars Westberg , Helgi B. Schiöth , Håkan Fischer

引用次数: 0

Abstract

The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N ≈ 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e., the oxytocin/neurophysin I prepropetide gene, the cluster of differentiation 38 glycoprotein gene, the oxytocin receptor gene) and whole-brain gray matter volume. Carriers of the AA or AG genotypes of the oxytocin receptor gene rs237851 SNP exhibited significantly larger hippocampal volume than carriers of the GG genotype. These results support the link between variations in the oxytocin receptor gene and hippocampal structure, with possible impact on social-cognitive function such as social recognition memory.

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催产素途径基因的遗传变异与海马体积之间的关系：来自英国生物银行的见解。

催产素相关基因在社会认知功能中的作用已经被确立，但是这种联系背后的大脑结构机制仍然知之甚少。利用来自英国生物银行（N≈30,000）的大量数据集，本研究确定了三个催产素途径基因（即催产素/神经physin I前肽基因，分化38糖蛋白簇基因，催产素受体基因）中十个单核苷酸多态性（snp）变异与全脑灰质体积之间的关系。催产素受体基因rs237851 SNP的AA或AG基因型携带者的海马体积明显大于GG基因型携带者。这些结果支持了催产素受体基因变异与海马体结构之间的联系，并可能影响社会认知功能，如社会识别记忆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.