DNA-Functionalized Solid-State Nanochannels with Enhanced Sensing

Abstract

After billions of years of evolution, organisms in nature have almost completed the intelligent manipulation of all life processes. Biological nanopores embedded in the cell membrane of organisms are representatives with intelligent manipulation capabilities. Biological nanopores can achieve controllable transmembrane transport of various ions and molecules, playing an important role in molecular biology processes such as substance exchange, signal transmission, energy conversion, and system function regulation in cells. Scientists have utilized biological nanopores for sensing analysis, such as gene sequencing and single-molecule detection. However, due to the characteristic that proteins (components of biological nanopores) cannot exist stably for a long time, scientists have developed solid-state nanopores/nanochannels with high mechanical strength, strong plasticity, and easy surface modification.