Dual-Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections

IF 18.5 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Gangfeng Li, Zhuoya Feng, Zishuo Hou, Runze Chen, Hannan Cui, Tengjiao Wang, Peng Li
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Abstract

Hydrogen selenide (H2Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such as high-dose toxicity and short half-life. Herein, a polymeric H2Se delivery nanogel (H2Se-NG) incorporated with aldehyde-modified selenobenzamide (SeAs) is designed for multidrug resistant (MDR) related healthcare-associated infections (HAIs) treatment. H2Se-NG facilitates a dual-cascade responsive release of H2Se over 72 h, effectively addressing the safety issues caused by the rapid hydrolysis of traditional inorganic H2Se delivery methods. In vitro and in vivo studies demonstrate that nontoxic doses of H2Se-NG at 150 µg mL−1 not only eliminated over 99% of MDR bacteria and their biofilm within 8 h while reducing levels of proinflammatory cytokines postinfection. Additionally, RNA sequencing results reveal that the released H2Se induces oxidative stress at infection site, kills biofilm-embedded methicillin-resistant Staphylococcus aureus (MRSA) and leads biofilm elimination by activating biofilm dispersion genes, suggesting the potential of H2Se-NG as a promising strategy in antibacterial gas therapy.

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来源期刊
Advanced Functional Materials
Advanced Functional Materials 工程技术-材料科学:综合
CiteScore
29.50
自引率
4.20%
发文量
2086
审稿时长
2.1 months
期刊介绍: Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.
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