Comparison of local minocycline hydrochloride delivery and antimicrobial photodynamic therapy as adjuncts to mechanical debridement for the treatment of peri‑implant mucositis: A randomized controlled trial

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104461

Abdulrahman M. AlMubarak

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引用次数: 0

Abstract

Objective

The aim was to compare the efficacy of local minocycline hydrochloride delivery (LMHD) and antimicrobial photodynamic therapy (aPDT) as adjuncts to mechanical debridement (MD) for the treatment of peri‑implant mucositis (PM).

Methods

Patients with PM were included. The following information was retrieved from patients’ digital dental records: (a) age, (b) gender, (c) duration of implants in function, (d) number of implants, (e) depth of implant placement, and (f) mode of prosthesis retention. Information related to daily toothbrushing and flossing of interproximal spaces and the most recent visit to an oral healthcare provider was also recorded. Participants were randomly divided into three groups as follows: (a) MD + LMHD; (b) MD + aPDT, and (c) MD alone. Peri-implant modified plaque index (mPI), modified gingival index (mGI) and probing depth (PD) were measured at baseline and at 45 days follow-up. Peri-implant crestal bone levels were measured at baseline. Group comparisons were done using One-way analysis of variance and Bonferroni post-hoc adjustment tests. The correlation between peri‑implant clinical parameters and age, gender, and duration of implants in function was assessed using linear regression analysis. Level of significance was set at P < 0.05.

Results

Twenty-two and 22 patients underwent MD with adjunct LMDH and aPDT, respectively. Twenty-two participants underwent MD alone. There was no difference in the mean ages of all individuals. At baseline, there was no difference in mPI, mGI and PD in all groups. At follow-up, mPI (P < 0.05), mGI (P < 0.05) and PD (P < 0.05) were higher among patients who underwent MD alone than individuals who received LMHD or aPDT as adjuncts to MD. There was no difference in mPI, mGI, and PD among individuals who underwent LMHD and aPDT as adjuvants to MD.

Conclusion

In the short term, MD with adjunct LMHD or aPDT is effective for managing PM.

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比较局部米诺环素和抗菌光动力治疗作为机械清创治疗种植体周围粘膜炎的辅助手段：一项随机对照试验。

目的：比较盐酸米诺环素局部给药（LMHD）与抗菌光动力治疗（aPDT）辅助机械清创（MD）治疗种植体周围粘膜炎（PM）的疗效。方法：纳入PM患者。从患者的数字牙科记录中检索以下信息：(a)年龄，(b)性别，(c)种植体功能持续时间，(d)种植体数量，(e)种植体放置深度，(f)种植体保留模式。与每日刷牙和使用牙线近端间隙有关的信息以及最近一次访问口腔保健提供者的信息也被记录下来。参与者随机分为以下三组：(a) MD + LMHD；(b) MD + aPDT，和(c)单独的MD。在基线和随访45 d时测量种植体周围改良菌斑指数（mPI）、改良牙龈指数（mGI）和探探深度（PD）。在基线时测量种植体周围嵴骨水平。采用单向方差分析和Bonferroni事后调整检验进行组间比较。使用线性回归分析评估种植体周围临床参数与年龄、性别和种植体功能持续时间的相关性。结果：分别有22例和22例患者接受MD合并LMDH和aPDT。22名参与者单独接受了MD治疗。所有个体的平均年龄没有差异。在基线时，各组mPI、mGI和PD均无差异。结论：在短期内，MD联合LMHD或aPDT治疗PM有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.