Factors Associated with Hepatocellular Carcinoma among Patients Receiving Treatment at the National Cancer Institute, Thailand: A Case-Control Study.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2024-12-01 DOI:10.31557/APJCP.2024.25.12.4169

Pattama Ploysawang, Suleeporn Sangrajrang

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引用次数: 0

Abstract

Background: Hepatocellular carcinoma (HCC) is a major public health concern in Thailand, ranking as the leading cause of cancer-related mortality in Thai people. This study aimed to identify various risk factors for HCC among patients treated at the National Cancer Institute (NCI) in Thailand.

Methods: The retrospective case-control study was conducted using secondary data sources from the Liver Cancer Prevention and Control Research project which was carried out at NCI from 2008 to 2010. A total of 200 cases diagnosed with HCC and 300 healthy controls were included in this study. Univariate analysis and multivariate logistic regression models were used to identify independent risk factors associated with HCC development. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to quantify the strength and significance of these associations.

Results: Our analysis showed that the mean ages of cases and controls were 52.2±7.7 years and 53.5±8.2 years respectively. After adjustment for gender, marital status, education, and income, the multivariable logistic regression analysis revealed a statistically significant association between HCC and several other factors. These included hepatitis B virus infection (OR 5.7, 95% CI 2.8-11.6), hepatitis C virus infection (OR 8.2, 95% CI 1.1-60.1) liver cirrhosis (OR 15.7, 95% CI 3.9-63.4), diabetes (OR 3.5, 95% CI 1.5-8.2), alcohol consumption (OR 3.2, 95% CI 1.7-5.9), and smoking status (OR 2.5, 95% CI 1.2-4.9).

Conclusions: Our findings contribute to the existing knowledge regarding risk factors for HCC among Thai people, particularly highlighting the emerging evidence that associates diabetes with HCC. This study provided baseline information for improving knowledge focused on preventing HCC and avoiding associated risk factors.

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泰国国家癌症研究所接受治疗的患者中与肝细胞癌相关的因素：一项病例对照研究

背景：肝细胞癌（HCC）是泰国主要的公共卫生问题，是泰国人癌症相关死亡的主要原因。本研究旨在确定在泰国国家癌症研究所（NCI）接受治疗的患者中发生HCC的各种危险因素。方法：采用2008 - 2010年NCI肝癌防治研究项目的二次资料进行回顾性病例对照研究。本研究共纳入200例诊断为HCC的病例和300例健康对照。使用单因素分析和多因素logistic回归模型来确定与HCC发展相关的独立危险因素。估计比值比（ORs）和95%置信区间（CIs）来量化这些关联的强度和显著性。结果：我们的分析显示，病例和对照组的平均年龄分别为52.2±7.7岁和53.5±8.2岁。在对性别、婚姻状况、教育程度和收入进行调整后，多变量logistic回归分析显示HCC与其他几个因素有统计学意义的相关性。包括乙型肝炎病毒感染（OR 5.7, 95% CI 2.8-11.6）、丙型肝炎病毒感染（OR 8.2, 95% CI 1.1-60.1）、肝硬化（OR 15.7, 95% CI 3.9-63.4）、糖尿病（OR 3.5, 95% CI 1.5-8.2）、饮酒（OR 3.2, 95% CI 1.7-5.9）和吸烟（OR 2.5, 95% CI 1.2-4.9）。结论：我们的研究结果有助于对泰国人HCC危险因素的现有认识，特别是强调了糖尿病与HCC相关的新证据。该研究为提高预防HCC和避免相关危险因素的知识提供了基线信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.