Efficacy and working mechanisms of a Go/No-Go task-based inhibition training in smoking: A randomized-controlled trial

IF 4.2 2区心理学 Q1 PSYCHOLOGY, CLINICAL

Behaviour Research and Therapy Pub Date : 2025-02-01 DOI:10.1016/j.brat.2024.104672

Franziska Motka , Charlotte E. Wittekind , Leonie Ascone , Simone Kühn

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引用次数: 0

Abstract

Objective

Deficits in inhibitory control contribute to smoking behavior. Inhibitory control training (ICT), which involves repeatedly inhibiting responses to general or substance-related stimuli, shows promise in reducing problematic substance use. This preregistered randomized-controlled trial is the first to investigate the efficacy of general and smoking-specific Go/No-Go task-based ICT on smoking behavior compared to control groups receiving no ICT. Three potential working mechanisms were examined: inhibitory enhancement, automatic stimulus-stop associations, and stimulus devaluation.

Method

Individuals who smoke (N = 122) were randomly assigned to complete 28 sessions of smoking-specific Go/No-Go, general Go/No-Go, Sham training, or to a Waitlist control condition. Clinical outcomes included daily cigarettes (primary outcome), carbon monoxide levels, tobacco dependence severity, and craving, assessed at post-intervention and 3-month follow-up.

Results

Go/No-Go training resulted in a significantly greater reduction in tobacco dependence (β = −0.88, p = .004) and craving (β = −4.31, p = .012) post-intervention compared to both control groups. The greater reduction in craving remained significant when compared to the Sham training group only (β = −4.64, p = .026). No significant effects of group were observed on daily cigarette consumption (β = −1.97, p = .093) or carbon monoxide levels (β = 2.16, p = .818) post-intervention. At the 3-month follow-up, no significant effects of group emerged (all ps > .794). Smoking-specific Go/No-Go training did not outperform general Go/No-Go training (all ps > .075). No working mechanism for clinical outcome improvements was identified.

Conclusions

Preliminary evidence suggests that (smoking-specific) GNG training reduces tobacco dependence severity and craving post-intervention in individuals who smoke compared to non-ICT-based control conditions. Its efficacy as an add-on in smoking cessation needs to be investigated.

Clinical trial registration number

DRKS00014652.

查看原文本刊更多论文

基于 "去/不去 "任务的吸烟抑制训练的效果和工作机制：随机对照试验。

目的：抑制控制缺陷与吸烟行为有关。抑制控制训练（ICT）涉及反复抑制对一般或物质相关刺激的反应，在减少有问题的物质使用方面显示出希望。这项预先注册的随机对照试验首次调查了与未接受ICT的对照组相比，一般和吸烟特定的Go/ no -Go任务型ICT对吸烟行为的影响。研究了三种潜在的工作机制：抑制增强、自动刺激-停止关联和刺激贬值。方法：吸烟的个体（N = 122）被随机分配完成28次吸烟特定的Go/No-Go、一般Go/No-Go、假训练或候补控制条件。临床结果包括每日吸烟（主要结果）、一氧化碳水平、烟草依赖严重程度和渴望，在干预后和3个月的随访中进行评估。结果：与两个对照组相比，Go/No-Go训练导致干预后烟草依赖（β = -0.88, p = 0.004）和渴望（β = -4.31, p = 0.012）的显著降低。与假训练组相比，更大的渴望减少仍然显着（β = -4.64, p = 0.026）。干预后，实验组对每日卷烟消费量（β = -1.97, p = 0.093）或一氧化碳水平（β = 2.16, p = .818）均无显著影响。随访3个月，两组无明显疗效（p < 0.05）。针对吸烟的“Go/No-Go”训练并不比一般的“Go/No-Go”训练表现更好（所有ps均为0.075）。没有确定临床结果改善的工作机制。结论：初步证据表明，与非基于信息通信技术的控制条件相比，（吸烟特定的）GNG培训降低了吸烟个体的烟草依赖严重程度和干预后的渴望。它作为戒烟辅助药物的功效需要调查。临床试验注册号：DRKS00014652。

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来源期刊

Behaviour Research and Therapy PSYCHOLOGY, CLINICAL-

CiteScore

7.50

自引率

7.30%

发文量

148

期刊介绍： The major focus of Behaviour Research and Therapy is an experimental psychopathology approach to understanding emotional and behavioral disorders and their prevention and treatment, using cognitive, behavioral, and psychophysiological (including neural) methods and models. This includes laboratory-based experimental studies with healthy, at risk and subclinical individuals that inform clinical application as well as studies with clinically severe samples. The following types of submissions are encouraged: theoretical reviews of mechanisms that contribute to psychopathology and that offer new treatment targets; tests of novel, mechanistically focused psychological interventions, especially ones that include theory-driven or experimentally-derived predictors, moderators and mediators; and innovations in dissemination and implementation of evidence-based practices into clinical practice in psychology and associated fields, especially those that target underlying mechanisms or focus on novel approaches to treatment delivery. In addition to traditional psychological disorders, the scope of the journal includes behavioural medicine (e.g., chronic pain). The journal will not consider manuscripts dealing primarily with measurement, psychometric analyses, and personality assessment.