Effect of Anaesthesia Technique on anti-tumor Immunity through TGF-β levels in Adult Patients Undergoing Surgery for Oral Cancer.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2024-12-01 DOI:10.31557/APJCP.2024.25.12.4257

Tanmay Mathur, Sachidanand Jee Bharti, Lata Kumari, Shivani Kaushik, Brajesh Kumar Ratre, Sushma Bhatnagar, Seema Mishra, Nishkarsh Gupta, Rakesh Garg, Vinod Kumar, Maroof Ahmad Khan, Sunil Kumar, Rakesh Kumar Deepak

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引用次数: 0

Abstract

Background: There is a paucity of literature regarding the effect of anesthetic techniques on anti-tumor immunity, especially in Oral cavity Malignancies. We designed a study to evaluate the effect of 3 anesthetic techniques - Opioid, Lignocaine infusion and Dexmeditomedine infusion-based on anti-tumor immunity, using TGF-β, T-helper cell profile and inflammatory markers such as IL-6 and IL-10.

Methods: A pilot prospective randomized trial was conducted in 90 patients undergoing surgery for Oral cavity malignancy under general anesthesia in a tertiary specialty cancer hospital. Adult cancer patients of the American Society of Anaesthesiologists (ASA) physical status I-III fulfilling the inclusion criteria were randomized to either group A (Opioid general anesthesia), group B (lignocaine infusion-based general anesthesia), or group C (Dexmedetomidine infusion-based general anesthesia). Preoperative (morning of surgery) and postoperative (24 hours after surgery) blood samples were obtained. Statistical analysis was done, and the results were analyzed.

Results: Demographic profile and pre-operative parameters were comparable between both groups. We did not find any statistically significant difference in the Post-operative levels of TGF-β, neutrophil-lymphocyte ratio (NLR), Monocyte Lymphocyte Ratio (MLR), platelet lymphocyte ratio (PLR), IL-6, IL-10, and T-helper cell profile( IFN-γ, IL-17A, and IL-4 as surrogate markers) among the three study groups. However, it was noted that the overall Opioid consumption was markedly reduced in Group C without any major adverse effects being noted.

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麻醉技术通过TGF-β水平对成年口腔癌手术患者抗肿瘤免疫的影响

背景：关于麻醉技术对抗肿瘤免疫的影响，特别是对口腔恶性肿瘤的影响，文献很少。我们设计了一项基于TGF-β、t辅助细胞谱和IL-6、IL-10等炎症标志物的研究，评估阿片类药物、利多卡因和右美托美定输注3种麻醉技术对抗肿瘤免疫的影响。方法：对某三级专科肿瘤医院全麻口腔恶性肿瘤手术患者90例进行前瞻性前瞻性随机试验。美国麻醉医师协会（ASA）身体状况I-III符合纳入标准的成年癌症患者随机分为A组（阿片类药物全麻）、B组（利多卡因输注全麻）或C组（右美托咪定输注全麻）。术前（手术当天上午）和术后（手术后24小时）采集血样。进行统计分析，并对结果进行分析。结果：两组的人口学特征和术前参数具有可比性。术后TGF-β水平、中性粒细胞-淋巴细胞比率（NLR）、单核细胞淋巴细胞比率（MLR）、血小板淋巴细胞比率（PLR）、IL-6、IL-10和t辅助细胞谱（IFN-γ、IL-17A和IL-4作为替代标志物）在三个研究组之间均无统计学差异。然而，值得注意的是，C组的阿片类药物总体消费量明显减少，没有发现任何重大不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.