Impact of IL13 genetic polymorphisms on COPD susceptibility in the Chinese Han population

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-02-01 DOI:10.1016/j.rmed.2024.107923

Zehua Yang , Yamei Zheng , Jie Zhao , Yi Zhong , Lei Zhang , Haihong Wu , Tian Xie , Yipeng Ding

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引用次数: 0

Abstract

Background

Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. Interleukin-13 (IL13), associated with T-helper type 2 cells, plays a crucial role in COPD pathophysiology. This study aimed to investigate the relationship of single nucleotide polymorphisms (SNPs) in IL13 to COPD risk.

Methods

Five candidate SNPs of IL13 were genotyped using MassARRAY iPLEX platform in a cohort of472 COPD patients and 472 healthy controls. Logistic regression analysis was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs). Additionally, Multifactor dimensionality reduction (MDR) software was utilized to assess the combined impact of SNP-SNP interactions on COPD risk.

Results

IL13 rs20541 (OR: 1.24, p: 0.028), rs1295685 (OR: 1.31, p: 0.006), rs848 (OR: 1.27, p: 0.016), and rs847 (OR: 1.30, p: 0.007) were associated with COPD risk. Moreover, IL13 variants were related to the increased COPD risk in females, individuals aged ≥68 year, non-smokers or non-drinkers. The optimal multi-locus model was identified as the combination of rs20541 and rs1295685.

Conclusion

Our findings indicated the association between IL13 variants and an elevated risk of developing COPD, especially rs1295685 and rs847. These findings could have implications for understanding the role of IL13 variants in COPD predisposition.

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IL13基因多态性对中国汉族COPD易感性的影响

背景：慢性阻塞性肺疾病（COPD）以持续的呼吸道症状和气流限制为特征。白细胞介素-13 （IL13）与辅助t型2细胞相关，在COPD病理生理中起着至关重要的作用。本研究旨在探讨IL13单核苷酸多态性（snp）与COPD风险的关系。方法：使用MassARRAY iPLEX平台对472名COPD患者和472名健康对照者的5个候选IL13 snp进行基因分型。采用Logistic回归分析计算优势比（ORs）和95%置信区间（ci）。此外，使用多因素降维（MDR）软件评估SNP-SNP相互作用对COPD风险的综合影响。结果：IL13 rs20541 （OR: 1.24, p: 0.028）、rs1295685 （OR: 1.31, p: 0.006）、rs848 （OR: 1.27, p: 0.016）和rs847 （OR: 1.30, p: 0.007）与COPD风险相关。此外，IL13变异与女性、年龄≥68岁、非吸烟者或非饮酒者COPD风险增加有关。结果表明，rs20541和rs1295685组合为最优多位点模型。结论：我们的研究结果表明，IL13变异与COPD发病风险升高之间存在关联，尤其是rs1295685和rs847。这些发现可能有助于理解IL13变异在COPD易感性中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.