Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the human prostate with aging

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2024-12-29 DOI:10.1002/mrm.30408

Xiao Ma, Peter Seres, Adam Kinnaird, Christopher Fung, Thorsten Feiweier, Christian Beaulieu

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引用次数: 0

Abstract

Purpose

The purpose of this study was to investigate microstructural changes in the aging adult prostate by comparing the effects of varying diffusion times using diffusion MRI, and to provide an age-related benchmark for future prostate cancer studies.

Methods

The prostates of normal male volunteers (n = 70, 19–69 years) were scanned at 3 T with an oscillating gradient spin echo (OGSE: 6 ms), pulsed gradient spin echo (PGSE: 40 ms) and pulsed gradient stimulated echo (PGSTE: 100 ms), and anatomical T₂-weighted image. Volume and mean diffusivity (MD) were measured in the peripheral (PZ) and transition zones (TZ), which were assessed versus age.

Results

PZ and TZ showed quadratic age trajectories for all diffusion scans, with MD decreasing from 19 years to a minimum ˜30–40 years followed by a greater increase at older ages. Short (OGSE) and medium (PGSE) diffusion time MD had similar age trajectories, whereas long diffusion time (PGSTE) MD was significantly lower, particularly in PZ (22%). MD difference (∆MD) of OGSE-PGSTE and PGSE-PGSTE showed significant positive linear correlations with age for both PZ (larger slope) and TZ, resulting in ˜3.3x (PZ) and 1.8x (TZ) greater ∆MD from 19 to 69 years. MD and ∆MD versus age relationships differed from volume, which conversely had greater proportional growth in TZ than PZ.

Conclusion

The diffusion time effects suggest age-related microstructural changes consistent with development of persistently larger cell dimensions mainly in the prostate peripheral zone over the adult lifespan. This normative data can be used for comparison to prostate cancer factoring in age.

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扩散时间效应在成人寿命表明持续区域特异性微结构改变在人类前列腺随着年龄的增长。

目的：本研究的目的是通过比较扩散MRI不同扩散时间对衰老成人前列腺微结构变化的影响，并为未来前列腺癌研究提供与年龄相关的基准。方法：采用振荡梯度自旋回波（OGSE: 6 ms）、脉冲梯度自旋回波（PGSE: 40 ms）和脉冲梯度刺激回波（PGSTE: 100 ms）扫描正常男性志愿者（n = 70, 19 ~ 69岁）的前列腺，并进行解剖t2加权成像。测量外周区（PZ）和过渡区（TZ）的体积和平均扩散率（MD），并根据年龄进行评估。结果：PZ和TZ在所有扩散扫描中都显示出二次年龄轨迹，MD从19岁下降到最小~ 30-40岁，随后随着年龄的增长而增加。短（OGSE）和中（PGSE）扩散时间MD具有相似的年龄轨迹，而长扩散时间（PGSTE） MD明显较低，特别是在PZ（22%）。在PZ（坡度较大）和TZ中，OGSE-PGSTE和PGSE-PGSTE的MD差异（∆MD）与年龄呈显著的线性正相关，导致19 ~ 69岁的∆MD增大~ 3.3倍（PZ）和1.8倍（TZ）。MD和∆MD与年龄的关系不同于体积，相反，TZ比PZ有更大的比例增长。结论：扩散时间效应提示年龄相关的微结构变化与前列腺外周区细胞尺寸持续变大的发展相一致。这一标准数据可用于与前列腺癌的年龄因素进行比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.