Centrilobular nodules are predictive chest computed tomography (CT) findings related to adult T-cell leukemia/lymphoma development in human T-lymphotropic virus type I carriers

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2025-02-01 DOI:10.1016/j.crad.2024.106765

H. Sato , F. Okada , Y. Asayama , M. Ogata , K. Takano , E. Ohtsuka

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引用次数: 0

Abstract

Aim

To evaluate predictive chest computed tomography (CT) findings associated with the development of adult T-cell leukemia/lymphoma (ATLL) in human T-lymphotropic virus type I (HTLV-1) carriers.

Materials and methods

This retrospective study examined 171 adult T-cell leukemia/lymphoma and 158 HTLV-1 carriers who were treated from November 2004 to April 2021. The radiological features of 888 chest CT scans in total were retrospectively assessed by two chest radiologists who were unaware of the underlying diagnoses and compared between the groups.

Results

In patients with aggressive type ATLL (acute type and lymphoma type), lymph node enlargement was the most frequently observed abnormality (65.2%), followed by ground-glass opacity (33.3%) and pleural effusion (30.4%). In patients with indolent type (chronic type and smoldering type), lymph node enlargement, and bronchiectasis were the most frequently observed abnormalities (5.6% and 5.6%, respectively). In each type, centrilobular nodules were observed in none and in one patient, respectively. In the 158 HTLV-1 carriers, centrilobular nodules (n = 62; 39.2%) were the most frequently observed abnormality. Centrilobular nodules were significantly frequently observed in HTLV-1 carriers compared with ATLL patients. No HTLV-1 carrier with centrilobular nodules on CT developed ATLL during the duration of care. A comparative analysis between CT scans performed before ATLL development in ATLL patients and those of HTLV-1 carriers showed that no centrilobular nodules were observed on the pre-ATLL CT scans, and a statistically-significant difference in centrilobular nodules was found between these two groups.

Conclusion

The presence of centrilobular nodules may be an indicative CT finding in HTLV-1 carriers who are less likely to develop ATLL.

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小叶中心结节是预测人类嗜t淋巴病毒I型携带者成人t细胞白血病/淋巴瘤发展的胸部计算机断层扫描（CT）结果。

目的：评价人类嗜t淋巴病毒I型（HTLV-1）携带者发生成人t细胞白血病/淋巴瘤（ATLL）的预测性胸部计算机断层扫描（CT）结果。材料和方法：本回顾性研究调查了2004年11月至2021年4月期间接受治疗的171例成人t细胞白血病/淋巴瘤和158例HTLV-1携带者。两名不知道潜在诊断的胸部放射科医生对总共888例胸部CT扫描的放射学特征进行回顾性评估，并在两组之间进行比较。结果：在侵袭型ATLL（急性型和淋巴瘤型）患者中，以淋巴结肿大最为常见（65.2%），其次为毛玻璃样混浊（33.3%）和胸腔积液（30.4%）。在惰性型（慢性型和闷烧型）患者中，淋巴结肿大和支气管扩张是最常见的异常（分别为5.6%和5.6%）。在每一种类型中，小叶中心结节分别为1例和1例。158例HTLV-1携带者中，小叶中心结节(n = 62；39.2%)是最常见的异常。HTLV-1携带者与ATLL患者相比，小叶中心结节的发生率明显更高。在护理期间，CT上显示有小叶中心结节的HTLV-1携带者未发生ATLL。ATLL患者与HTLV-1携带者在ATLL发生前的CT扫描对比分析显示，ATLL发生前的CT扫描未发现小叶中心结节，两组间小叶中心结节的发生率差异有统计学意义。结论：小叶中心结节的存在可能是HTLV-1携带者不太可能发展为ATLL的指示性CT发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.