Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy.

IF 2.1 4区 医学 Q3 INFECTIOUS DISEASES
Francesca Lombardi, Simone Belmonti, Alessia Sanfilippo, Alberto Borghetti, Valentina Iannone, Pierluigi Francesco Salvo, Massimiliano Fabbiani, Elena Visconti, Simona Di Giambenedetto
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Abstract

Background: Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). We aimed to assess factors associated with OS in virologically suppressed PLWH on long-term modern ART.

Method: In this cross-sectional study we evaluated OS by measuring both the levels of derivatives-reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP). We also calculated the BAP/d-ROMs ratio, (OS index, OSi); a cut-off value < 7.3 indicated OS. Factors associated with OS markers were explored by linear regression model.

Results: We enrolled 299 experienced PLWH with virological suppression (HIV-RNA < 50cps/mL). The mean of the d-ROMs levels was 409 UCARR (95%CI 394-422), whereas the mean of the BAP levels was 1.809 µmol/L (95%CI 1706-1851). The OSi mean value was 4.84, and 91.6% of the participants were below the cut-off value. By regression analysis, higher production of oxidants was associated with female sex (p < 0.001), current exposition to PIs (p = 0.030) and HCV co-infection (p = 0.006). Higher antioxidant capacity was correlated with higher HDL levels (p = 0.001). A lower OSi was associated with female sex (p = 0.003) and the current use of triple vs. dual regimen (p = 0.036). The OSi correlated negatively with cholesterol levels (p = 0.002) and positively with HDL (p < 0.001).

Conclusions: Virologically suppressed PLWH on long-term ART showed a marked OS. Female sex, the exposure to PIs, and HCV co-infection were associated with higher oxidants, while higher HDL levels were linked to better antioxidant capacity. Interestingly, dual therapy, especially INSTI-based regimens, was associated with lower oxidative stress compared to triple therapy.

长期接受抗逆转录病毒治疗、病毒学抑制的艾滋病病毒感染者体内氧化应激的相关因素。
背景:氧化应激(OS)是指氧化剂分子和抗氧化剂分子之间的不平衡,它与接受抗逆转录病毒疗法(ART)治疗的艾滋病病毒感染者(PLWH)发病和死亡风险的增加有关。我们旨在评估长期接受现代抗逆转录病毒疗法的病毒学抑制型艾滋病病毒感染者的OS相关因素:在这项横断面研究中,我们通过测量衍生反应氧代谢物(d-ROMs)和生物抗氧化潜能(BAP)的水平来评估OS。我们还计算了 BAP/d-ROMs 比率(OS 指数,OSi);这是一个临界值:我们招募了 299 名病毒学抑制(HIV-RNA 结论)的有经验的 PLWH:长期接受抗逆转录病毒疗法的病毒学抑制的 PLWH 显示出明显的 OS。女性性别、PIs 暴露和 HCV 合并感染与较高的氧化剂有关,而较高的 HDL 水平与较好的抗氧化能力有关。有趣的是,与三联疗法相比,双重疗法(尤其是基于 INSTI 的疗法)与较低的氧化应激有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIDS Research and Therapy
AIDS Research and Therapy INFECTIOUS DISEASES-
CiteScore
3.80
自引率
4.50%
发文量
51
审稿时长
16 weeks
期刊介绍: AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
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