The impact of type 2 diabetes on melanoma stage (TNM) at the time of diagnosis and its association with sex: A Danish nationwide study

IF 2.4 3区 医学 Q3 ONCOLOGY
Jens Ejrnæs Tønder , Eeva-Liisa Røssell , Martin Sollie , Marie Louise Bønnelykke-Behrndtz , Tinne Laurberg
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引用次数: 0

Abstract

Background

Cancer has become the leading cause of death among individuals with type 2 diabetes (T2D) in high-income countries. T2D is suggested to directly influence cancer progression. However, the association between T2D and melanoma stage at diagnosis remains uncertain, as well as any potential sex disparities.

Objectives

To investigate the association between T2D and the melanoma TNM stage (Breslow thickness, ulceration status, lymph node metastases, and distant metastases) at the time of diagnosis and to assess whether the association is affected by sex.

Methods

A nationwide cross-sectional study was conducted, including all patients diagnosed with melanoma between 2004 and 2022 identified in the Danish Cancer Register. T2D status was ascertained using a validated register based algorithm. The association between T2D and melanoma stage was estimated using univariable and multivariable logistic regression analyses adjusted for sex, age, comorbidity, and year of diagnosis.

Results

The study included 30,315 individuals with melanoma. The multivariable analyses showed that T2D was associated with an increased adjust odds ratio (aOR) of tumour thickness > 4 mm (aOR 1.30, 95 %CI: [1.10–1.52]), the presence of ulceration (aOR: 1.25, 95 % CI: [1.09–1.43]), lymph node metastases (aOR 1.27 [1.10–1.47]), and distant metastases (aOR: 1.26 [1.01–1.56]). Furthermore, sex stratified analyses showed that T2D was associated with distant metastases in women, but not in men.

Conclusions

Individuals with T2D were more likely to be diagnosed with advanced stages of local, regional, and distant melanoma. This highlights the need for greater melanoma awareness and further research into treatment responses in individuals with T2D.
2型糖尿病对诊断时黑色素瘤分期(TNM)的影响及其与性别的关系:一项丹麦全国性研究。
背景:癌症已成为高收入国家2型糖尿病(T2D)患者死亡的主要原因。T2D被认为直接影响癌症的进展。然而,T2D与黑色素瘤诊断阶段之间的关系以及任何潜在的性别差异仍然不确定。目的:探讨诊断时T2D与黑色素瘤TNM分期(brreslow厚度、溃疡状态、淋巴结转移和远处转移)之间的关系,并评估这种关系是否受性别影响。方法:进行了一项全国性的横断面研究,包括2004年至2022年间在丹麦癌症登记处发现的所有被诊断为黑色素瘤的患者。使用一种有效的基于寄存器的算法确定T2D状态。利用单变量和多变量logistic回归分析对性别、年龄、合并症和诊断年份进行校正,估计T2D与黑色素瘤分期之间的关系。结果:该研究包括30315名黑色素瘤患者。多变量分析显示,T2D与肿瘤厚度> 4 mm (aOR 1.30, 95 %CI:[1.10-1.52])、溃疡(aOR: 1.25, 95 %CI:[1.09-1.43])、淋巴结转移(aOR 1.27[1.10-1.47])和远处转移(aOR: 1.26[1.01-1.56])的调整优势比(aOR)增加相关。此外,性别分层分析显示,T2D与女性的远处转移有关,而与男性无关。结论:T2D患者更有可能被诊断为局部、区域和远处黑色素瘤的晚期。这突出了对黑色素瘤的认识和对T2D患者治疗反应的进一步研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Epidemiology
Cancer Epidemiology 医学-肿瘤学
CiteScore
4.50
自引率
3.80%
发文量
200
审稿时长
39 days
期刊介绍: Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.
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