Targeting the ubiquitin proteasome system in cancer stem cells.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI:10.1016/j.tcb.2024.11.011

Hind Atta, Dina H Kassem, Mohamed M Kamal, Nadia M Hamdy

引用次数: 0

Abstract

Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype. This forum article aims to outline new strategies/technologies targeting UPS modulation in CSCs as a potential novel modality for efficient cancer therapy.

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靶向肿瘤干细胞中的泛素蛋白酶体系统。

在过去几年中，世界范围内的癌症负担出现了惊人的激增。癌症干细胞（CSCs）在肿瘤中扮演着隐藏的魔鬼的角色，使癌症治疗成为一项艰巨的目标。最近，泛素蛋白酶体系统（UPS）被证明是CSC表型的重要贡献者。这篇论坛文章旨在概述针对csc中UPS调节的新策略/技术，作为有效癌症治疗的潜在新模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.