Mechanical function of the annulus fibrosus is preserved following quasi-static compression resulting in endplate fracture

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-02-01 DOI:10.1016/j.clinbiomech.2024.106425

John G. McMorran , Andra Neptune , Diane E. Gregory

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引用次数: 0

Abstract

Background

Vertebral fractures in young populations are associated with intervertebral disc disorders later in life. However, damage to the annulus fibrosus has been observed in rapidly loaded spines even without the subsequent occurrence of a fracture. Therefore, it may not be the fracture event that compromises the disc, but rather the manner in which the disc is loaded. The purpose of this study was to quantify the mechanical properties of the annulus fibrosus following quasi-static compressive loading of the motion segment either to sub-fracture or fracture-inducing magnitude.

Methods

Porcine cervical motion segments were axial compressed at 0.1 mm/s, either until endplate fracture occurred (‘fracture group’), or until segments reached 75 % of average fracture stress as determined from the fracture group (‘sub-fracture group’). An unloaded control group was also included. Post-loading, three samples of the annulus were excised. The first was mounted in a 180^o peel test configuration in order to quantify lamellar adhesion. The other two samples were excised from the superficial and midspan region of the annulus and were exposed to uniaxial tension to 50 % strain.

Findings

Lamellar adhesion and tensile annulus mechanics did not differ between the fracture and sub-fracture group, nor between the unloaded controls.

Interpretation

Given the lack of differences in annular mechanical properties across the three conditions, it was concluded that under very slow, quasi-static compressive loading conditions, the annulus appeared undamaged even in the group that sustained a fracture; this is likely because a significant viscoelastic response was not generated in the disc under these slow loading conditions.

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准静态压缩导致终板骨折后，纤维环的力学功能得以保留。

背景：年轻人群的椎体骨折与以后的椎间盘疾病有关。然而，在快速加载的脊柱中，即使没有随后发生骨折，也会观察到纤维环的损伤。因此，影响椎间盘的可能不是骨折事件，而是椎间盘的受力方式。本研究的目的是量化运动节段在准静态压缩载荷下纤维环的力学特性，无论是亚骨折还是诱发骨折的程度。方法：以0.1 mm/s的速度轴向压缩猪颈椎运动节段，直到终板发生骨折（“骨折组”），或者直到节段达到骨折组平均骨折应力的75%（“亚骨折组”）。另外还包括一个未加载的对照组。加载后，切除三个环样。第一个是安装在180剥离测试配置，以量化板层附着力。另外两个样品从环的表面和跨中区域切除，暴露于单轴拉伸至50%应变。研究结果：骨折组和亚骨折组之间板层粘连和拉伸环空力学没有差异，在未加载的对照组之间也没有差异。解释：考虑到三种情况下环空力学性能没有差异，可以得出结论，在非常缓慢的准静态压缩加载条件下，即使在发生断裂的组中，环空也没有损坏；这可能是因为在这些缓慢加载条件下，圆盘没有产生明显的粘弹性响应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.