Preclinical RA: How to halt its progression

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-03-01 DOI:10.1016/j.berh.2024.102030

Tong Wu , Yanhong Li , Yi Liu , Cong-Qiu Chu

引用次数: 0

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder with a complex pathogenesis that evolves through various stages before clinical symptoms emerge. This review outlines the natural history of RA, starting from genetic predisposition and environmental triggers to preclinical autoimmunity and subsequent joint inflammation. Key genetic factors interact with environmental elements like smoking and infections, producing autoantibodies such as anti-citrullinated protein antibodies (ACPA) and rheumatoid factor, which precede clinical manifestations by several years. The preclinical phases offer critical opportunities for intervention aiming at halting disease progression. Preventive strategies including lifestyle modifications, dietary interventions, and targeted immune modulation may halt the progression to clinical RA in those at-risk individuals.

查看原文本刊更多论文

临床前类风湿性关节炎：如何阻止其进展。

类风湿性关节炎（RA）是一种慢性自身免疫性疾病，其发病机制复杂，在出现临床症状之前可经历不同阶段。这篇综述概述了风湿性关节炎的自然历史，从遗传易感性和环境触发到临床前自身免疫和随后的关节炎症。关键的遗传因素与吸烟和感染等环境因素相互作用，产生抗瓜氨酸蛋白抗体（ACPA）和类风湿因子等自身抗体，这些抗体比临床表现早几年出现。临床前阶段为旨在阻止疾病进展的干预提供了关键机会。包括生活方式改变、饮食干预和靶向免疫调节在内的预防策略可能会阻止这些高危人群向临床类风湿性关节炎的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.