Transcription factor–mediated reprogramming to antigen-presenting cells

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-02-01 DOI:10.1016/j.gde.2024.102300

Ervin Ascic , Carlos-Filipe Pereira

引用次数: 0

Abstract

Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explored to generate APC subsets, including enrichment from peripheral blood and differentiation from pluripotent or multipotent cells. During development, the generation of APC subsets is instructed by transcription factors (TFs). Direct cell reprogramming, also known as transdifferentiation, offers an approach to harness combinations of TFs to generate APCs from unrelated somatic cells, including cancer cells. In this review, we summarize the transcriptional specification of DC subsets, highlight transcriptional networks for their generation, and discuss future applications of DC reprogramming in cancer immunotherapy.

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转录因子介导的抗原呈递细胞重编程。

抗原呈递细胞（APCs）是由树突状细胞（dc）和巨噬细胞（mφ）组成的异质免疫细胞群，它们对协调免疫对抗癌症或感染至关重要。已经探索了几种产生APC亚群的策略，包括从外周血富集和从多能或多能细胞分化。在发育过程中，APC亚群的产生是由转录因子（tf）指导的。直接细胞重编程，也称为转分化，提供了一种利用tf组合从不相关的体细胞（包括癌细胞）中产生apc的方法。在这篇综述中，我们总结了DC亚群的转录规范，重点介绍了它们产生的转录网络，并讨论了DC重编程在癌症免疫治疗中的未来应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)