{"title":"Osteoarthritis: An integrative overview from pathogenesis to management.","authors":"W Zhao, Y Long, Y Wang, K Y Chin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoarthritis (OA) is a prevalent degenerative joint disease characterised by cartilage and subchondral bone breakdown, impacting millions worldwide. This review provides an overview of the complex aetiology of OA, integrating biochemical, mechanical, and genetic factors. It also emphasises a multifaceted management approach, combining non-pharmacological, pharmacological, and surgical treatments. Non-pharmacological strategies include physical therapy and lifestyle changes, which are crucial for pain relief and functional improvement. Pharmacological options focus on non-steroidal anti-inflammatory agents and emerging disease-modifying drugs, while surgical interventions are reserved for advanced cases. The review also explores the potential of regenerative medicine and personalised treatments in revolutionising OA management. Additionally, it underscores the importance of advanced diagnostic tools in early disease detection and monitoring, paving the way for timely and effective interventions.</p>","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"369-378"},"PeriodicalIF":0.6000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Malaysian Journal of Pathology","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoarthritis (OA) is a prevalent degenerative joint disease characterised by cartilage and subchondral bone breakdown, impacting millions worldwide. This review provides an overview of the complex aetiology of OA, integrating biochemical, mechanical, and genetic factors. It also emphasises a multifaceted management approach, combining non-pharmacological, pharmacological, and surgical treatments. Non-pharmacological strategies include physical therapy and lifestyle changes, which are crucial for pain relief and functional improvement. Pharmacological options focus on non-steroidal anti-inflammatory agents and emerging disease-modifying drugs, while surgical interventions are reserved for advanced cases. The review also explores the potential of regenerative medicine and personalised treatments in revolutionising OA management. Additionally, it underscores the importance of advanced diagnostic tools in early disease detection and monitoring, paving the way for timely and effective interventions.
期刊介绍：
The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.
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