ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal inflammatory response.

IF 0.6 4区医学 Q4 PATHOLOGY

Malaysian Journal of Pathology Pub Date : 2024-12-01

B S Hanim, Y P Wong, G C Tan, N Abd Shukor

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引用次数: 0

Abstract

Introduction: ICAM-1 is an adhesion molecule expressed on the endothelial cells and is involved in regulating leukocyte recruitment to the site of inflammation. Elevated ICAM-1 mRNA expression was found in the serum of mothers with chorioamnionitis. This study aimed to determine the expression of ICAM-1 in the placenta and umbilical cord of pregnancy with chorioamnionitis, and its association with adverse neonatal outcome.

Materials and methods: This study comprised a total of 86 cases of which there were 35 cases of non-chorioamnionitis and 51 cases of chorioamnionitis consisting of acute subchorionitis/chorionitis (maternal inflammatory response (MIR) stage 1, n=17), acute chorioamnionitis (MIR stage 2, n=17) and acute necrotising chorioamnionitis (MIR stage 3, n=17). Formalin-fixed paraffin embedded placenta tissue blocks were retrieved from the histopathology archive. ICAM-1 immunohistochemistry was performed on all cases and their expressions were evaluated on cells of the umbilical vein, umbilical artery, foetal vessels and maternal vessels.

Results: The expression of ICAM-1 in umbilical vein was significantly associated with cases of foetal inflammatory response (p<0.001).

Conclusion: We found that ICAM-1 expression was upregulated in the endothelial cells of umbilical vein in acute chorioamnionitis with positive foetal inflammatory response. ICAM-1 might be involved in the pathogenesis of acute chorioamnionitis and funisitis. Further study using a larger cohort is needed to strengthen this observation.

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来源期刊

Malaysian Journal of Pathology PATHOLOGY-

CiteScore

3.60

自引率

5.60%

发文量

期刊介绍： The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.