The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2025-01-01 DOI:10.1016/j.dsx.2024.103182

Botao Zhu, Chenghui Cao, Wenwu Liu, Yuxuan Liu, Yonghong Luo, Daoquan Peng

{"title":"The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study","authors":"Botao Zhu, Chenghui Cao, Wenwu Liu, Yuxuan Liu, Yonghong Luo, Daoquan Peng","doi":"10.1016/j.dsx.2024.103182","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>This study seeks to evaluate the prognostic significance of eGDR in predicting mortality outcomes within non-diabetic older adults.</div></div><div><h3>Methods</h3><div>8131 non-diabetic participants aged ≥60 years from the National Health and Nutrition Examination Survey (2001–2018) was included in this study. eGDR was calculated as: eGDR (mg/kg/min) = 21.158 – [0.09 × waist circumference (cm)] – [3.407 × Hypertension (Yes = 1/No = 0)] – [0.551 × HbA1c (%)]. Weighted Cox proportional hazards models, cumulative hazard curves, restricted cubic spline (RCS), and threshold effects analyses were performed to explore the relationship between eGDR and mortality outcomes. Subgroup analyses and mediation effects analyses were conducted.</div></div><div><h3>Results</h3><div>2566 all-cause deaths and 689 cardiovascular deaths were recorded. Lower eGDR was associated with higher all-cause (HR = 0.76, 95 % CI: 0.63–0.91) and cardiovascular mortality (HR = 0.56, 95 % CI: 0.40–0.80). Inflection points were identified through RCS curve analyses, and the threshold effect was significant. The eGDR-mortality association remained consistent across subgroups. Mediation analyses showed that neutrophil to high-density lipoprotein cholesterol ratio mediated the association.</div></div><div><h3>Conclusions</h3><div>Lower eGDR levels are linked to higher risk of both all-cause and cardiovascular mortality in non-diabetic older adults, suggesting its potential utility for risk assessment among this population.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"19 1","pages":"Article 103182"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1871402124002431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

This study seeks to evaluate the prognostic significance of eGDR in predicting mortality outcomes within non-diabetic older adults.

Methods

8131 non-diabetic participants aged ≥60 years from the National Health and Nutrition Examination Survey (2001–2018) was included in this study. eGDR was calculated as: eGDR (mg/kg/min) = 21.158 – [0.09 × waist circumference (cm)] – [3.407 × Hypertension (Yes = 1/No = 0)] – [0.551 × HbA1c (%)]. Weighted Cox proportional hazards models, cumulative hazard curves, restricted cubic spline (RCS), and threshold effects analyses were performed to explore the relationship between eGDR and mortality outcomes. Subgroup analyses and mediation effects analyses were conducted.

Results

2566 all-cause deaths and 689 cardiovascular deaths were recorded. Lower eGDR was associated with higher all-cause (HR = 0.76, 95 % CI: 0.63–0.91) and cardiovascular mortality (HR = 0.56, 95 % CI: 0.40–0.80). Inflection points were identified through RCS curve analyses, and the threshold effect was significant. The eGDR-mortality association remained consistent across subgroups. Mediation analyses showed that neutrophil to high-density lipoprotein cholesterol ratio mediated the association.

Conclusions

Lower eGDR levels are linked to higher risk of both all-cause and cardiovascular mortality in non-diabetic older adults, suggesting its potential utility for risk assessment among this population.

查看原文本刊更多论文

在美国年龄≥60岁的非糖尿病人群中，估计葡萄糖处置率对全因死亡率和心血管死亡率的预测价值：一项基于人群的队列研究

目的：本研究旨在评估eGDR在预测非糖尿病老年人死亡结局中的预后意义。方法：从2001-2018年全国健康与营养调查中纳入8131名年龄≥60岁的非糖尿病参与者。eGDR计算公式为：eGDR (mg/kg/min) = 21.158 - [0.09 ×腰围（cm）] - [3.407 ×高血压（是= 1/否= 0）]- [0.551 ×糖化血红蛋白（%）]。采用加权Cox比例风险模型、累积风险曲线、受限三次样条（RCS）和阈值效应分析来探讨eGDR与死亡率结局之间的关系。进行亚组分析和中介效应分析。结果：全因死亡2566例，心血管死亡689例。较低的eGDR与较高的全因死亡率（HR = 0.76, 95% CI: 0.63-0.91）和心血管死亡率（HR = 0.56, 95% CI: 0.40-0.80）相关。通过RCS曲线分析确定拐点，阈值效应显著。egdr与死亡率的关联在各亚组之间保持一致。中介分析表明，中性粒细胞与高密度脂蛋白胆固醇的比值介导了这种关联。结论：在非糖尿病老年人中，较低的eGDR水平与较高的全因死亡率和心血管死亡率相关，提示其在该人群中风险评估的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.