Cortical and subcortical gray matter volume and cognitive impairment in Parkinson's disease.

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2024-12-27 DOI:10.1080/23279095.2024.2443591

Naser Moradi, Siamak Shahidi, Mohammad Ahmadpanah, Sajjad Farashi, Ghodratollah Roshanaei

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Abstract

Introduction: This study investigated the cortical and subcortical gray matter volume (GMV) and cognitive impairment (CI) in patients with Parkinson's disease (PD).

Methods: In this study, T1-weighted magnetic resonance imaging of the cortex and subcortex was conducted on 92 individuals diagnosed with PD and 92 healthy controls (HCs). PD patients were divided into three groups: PD with normal cognition (PD-NC, n = 21), PD with mild CI (PD-MCI, n = 43), and PD with severe CI (PD-SCI, n = 28). Differences in GMV were analyzed using voxel-based morphometry (VBM). Statistical analysis was conducted using SPSS 26.

Results: Compared to the HCs, the PD-NC group exhibited reduced GMV in the right middle frontal gyrus (RMFG), right precentral gyrus medial segment (RPGMS), left temporal pole, and right superior frontal gyrus medial segment (RSFGMS). In comparison to the HC and PD-NC groups, the PD-MCI and PD-SCI groups (respectively) demonstrated significant decreases in GMV in the right caudate, left hippocampus, left thalamus, RMFG, RPGMS, RSFGMS, and cerebellum (right crus I and left crus I). The regression analysis indicated that changes in the GMV of the frontal areas can predict cognitive test outcomes.

Conclusion: Compared to HCs, PD patients with CI presented significant volume reductions in the RC, LH, LT, RMFG, RPGMS, RSFGMS, and the right and left crus I regions. Consequently, as average GMV atrophy increased in the specified regions, PD patients exhibited more severe cognitive impairment than the HC group. This may be attributed to the initial pathological loss of frontal GMV (especially in the RMFG and RPGMS regions), which could subsequently lead to subcortical dysfunction.

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帕金森病的皮层和皮层下灰质体积与认知障碍。

摘要：本研究探讨了帕金森病（PD）患者皮层和皮层下灰质体积（GMV）与认知功能障碍（CI）的关系。方法：在本研究中，对92例诊断为PD的个体和92例健康对照（hc）进行了皮层和皮层下的t1加权磁共振成像。将PD患者分为认知正常PD （PD- nc, n = 21）、轻度CI PD （PD- mci, n = 43）、重度CI PD （PD- sci, n = 28）三组。使用基于体素的形态测量（VBM）分析GMV的差异。采用SPSS 26进行统计学分析。结果：PD-NC组与hc组相比，右侧额叶中回（RMFG）、右侧中央前回内侧段（RPGMS）、左侧颞极和右侧额叶上回内侧段（RSFGMS）的GMV均有所降低。与HC组和PD-NC组相比，PD-MCI组和PD-SCI组（分别）显示右侧尾状核、左侧海马、左侧丘脑、RMFG、RPGMS、RSFGMS和小脑（右小腿I和左小腿I）的GMV显著降低。回归分析表明，额叶GMV的变化可以预测认知测试结果。结论：与hcc相比，PD合并CI患者RC、LH、LT、RMFG、RPGMS、RSFGMS以及左右小腿I区体积明显减少。因此，随着特定区域GMV平均萎缩的增加，PD患者表现出比HC组更严重的认知障碍。这可能归因于额叶GMV（尤其是RMFG和RPGMS区域）的初始病理性丧失，这可能随后导致皮质下功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.