Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2024-12-26 DOI:10.12998/wjcc.v12.i36.6939

Kang-Ming Huang, Hong-Bin Chen, Jin-Rong Lin

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Abstract

Traditional Chinese medicine has a long and illustrious history, and with the development of modern science and technology, the research and application of traditional Chinese medicines have continued to progress significantly. Many traditional Chinese medicinal herbs have undergone scientific validation, reinvigorating with new life and vitality, and contributing unique strengths to the advancement of human health. Recently, the discovery that leech total protein extracted from Poecilobdella manillensis lyophilized powder reduces blood uric acid (UA) levels by inhibiting the activity of xanthine oxidase to decrease UA synthesis and promotes UA excretion by regulating different UA transporters in the kidney and intestine has undoubtedly injected new vitality and hope into this field of research. The purpose of this editorial is to comment on this study, explore its strengths and weaknesses, and there is a hope to treat a range of metabolic-related syndromes, including hyperuricemia, by targeting the gut microbiota.

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中药冬青冻干粉治疗高尿酸血症的潜力。

中医药有着悠久而辉煌的历史，随着现代科学技术的发展，中医药的研究和应用不断取得重大进展。许多中草药经过科学验证，焕发出新的生命和活力，为促进人类健康贡献了独特的力量。近年来，从水蛭冻干粉中提取的水蛭总蛋白通过抑制黄嘌呤氧化酶活性降低血尿酸（UA）水平，从而减少UA的合成，并通过调节肾脏和肠道中不同的UA转运蛋白促进UA的排泄，这一发现无疑为这一研究领域注入了新的活力和希望。这篇社论的目的是对这项研究进行评论，探讨其优点和缺点，并希望通过靶向肠道微生物群来治疗一系列代谢相关综合征，包括高尿酸血症。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.