The Relationship Between Muscle Metabolic Index (Cr/CysC) Levels and Short-Term Prognosis with Acute Ischemic Stroke: Findings from a Cohort Study.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-01-11 DOI:10.1016/j.wneu.2024.123596

Min Dou, Xia Chen, Qiongdan Hu, Ying Jiang, Zixuan Wei, Yuanyuan Mi, Shanbing Hou, Qanqan Sun, Dandan Yuan, Jing Fang

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引用次数: 0

Abstract

Objective: Sarcopenia significantly impacts prognosis in patients with acute ischemic stroke (AIS). This study investigates the relationship between serum creatinine/serum cystatin C (Cr/CysC) levels and short-term prognosis in AIS patients, aiming to inform post-treatment strategies.

Methods: We analyzed AIS patients at the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to January 2024. Baseline data were collected through interviews and medical records, with a 3-month follow-up for prognosis assessment. 265 were included in the final analysis. Cr/CysC levels were categorized into quartiles (Q1-Q4). Logistic regression and restricted cubic spline analysis were employed to evaluate the association between Cr/CysC and prognosis.

Results: Among the 265 patients, the average age was 66.18 ± 12.41 years, and 129 (48.68%) had poor short-term prognosis. Multivariate logistic regression showed that patients in the lowest quartile of Cr/CysC (Q1) had a significantly lower risk of poor prognosis compared to those in the highest quartile (Q4) (odds ratio = 0.287, 95% confidence interval: 0.090-0.917, P = 0.035). A linear relationship was identified between Cr/CysC and prognosis (P overall<0.001, P nonlinear = 0.571).

Conclusions: This study establishes a significant linear correlation between Cr/CysC levels and poor short-term prognosis in AIS patients. Encouraging muscle function exercises may enhance patient outcomes.

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Cr/CysC水平与急性缺血性脑卒中短期预后的关系：一项队列研究的结果

目的：肌少症对急性缺血性脑卒中（AIS）患者预后有显著影响。本研究探讨了AIS患者血清肌酐/胱抑素C （Cr/CysC）水平与短期预后的关系，旨在为AIS患者的治疗策略提供依据。方法：对中国科学技术大学第一附属医院2022年1月至2024年1月的AIS患者进行分析。通过访谈和医疗记录收集基线数据，并进行为期三个月的预后评估随访。265人被纳入最终分析。Cr/CysC水平分为四分位数（Q1-Q4）。采用Logistic回归和限制性三次样条分析评价Cr/CysC与预后的关系。结果：265例患者中，平均年龄66.18±12.41岁，短期预后不良129例（48.68%）。多因素logistic回归分析显示，Cr/CysC最低四分位数（Q1）患者预后不良风险明显低于最高四分位数（Q4）患者（OR = 0.287, 95% CI: 0.090 ~ 0.917, P = 0.035）。结论：本研究确立了Cr/CysC水平与AIS患者短期预后不良之间存在显著的线性相关。鼓励肌肉功能锻炼可能会提高患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS