The Relationship Between Ambulatory Blood Pressure and Atherogenic Index with LV Geometry Pattern in Obese Children: Results from a Cross-Sectional Study in Serbia.

IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Bjelakovic Bojko, Stefanutti Claudia, Vukovic Vladimir, Klisic Aleksandra, Stojkovic Stefan, Jovic Marko, Bjelakovic Ilija, Banach Maciej
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Abstract

Arterial hypertension and increased atherogenic index of plasma (AIP) are strong predictors of cardiovascular risk associated in individuals with obesity both in adults and children. Thus, we aimed to explore the relationship between AIP and systolic ambulatory blood pressure index (sABPI) with left ventricular geometry pattern in obese children. In this cross-sectional study, a total of 129 obese children (BMI greater or equal to the 95th percentile for age and sex) were examined. Fasting blood samples were taken to measure plasma glucose level, lipid profile, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), serum uric acid (SUA), and insulin level. Two-dimensional (2-D) transthoracic echocardiography was performed to determine left ventricular geometry pattern. Ambulatory blood pressure recording was obtained for 24 h in all obese children. Linear regression analyses were conducted to explore relationships between AIP (calculated as logarithmic transformation of the ratio of TG to HDL-C) and sABPI with left ventricular myocardial mass index (LVMI) and relative wall thickness (RWT). We also used sex as a potential effect modifier, and calculated stratum-specific estimates of the effect. We demonstrated independent and positive association of age and AIP with RWT (Age: effect size = 0.83 (CI 0.22 - 1.45) p = 0.008; AI effect size 8.9 (CI 3.6 - 14.3); p = 0.01). In a subgroup analysis with sex as an effect modifier, independent positive association of borderline significance at p = 0.011 was found between AIP and RWT only in boys AIP: effect size 9.5 (CI 2.3 - 16.7) p = 0.01. LVMI was significantly associated with sex and BMI (sex: effect size = 6.8 CI (2.6 - 11) p = 0.002; BMI z score: effect size = 6.8 CI (3.2-10.4) p < 0.001). Independent positive association was also found between BMI and LVMI for girls, effect size = 11.9 (CI 4.1-19.8) (p = 0.005). AIP and age are independently associated with the presence of concentric left ventricular geometry with girls seeming more protected from atherogenic hypertrophic stimulus than boys. BMI and sex are independently associated with eccentric left ventricular remodeling, with BMI being a greater risk factor for girls.

肥胖儿童动态血压和动脉粥样硬化指数与左室几何形态的关系:塞尔维亚横断面研究的结果。
动脉高血压和血浆动脉粥样硬化指数(AIP)升高是成人和儿童肥胖患者心血管风险的有力预测因子。因此,我们的目的是探讨AIP和收缩期动态血压指数(sABPI)与肥胖儿童左心室几何模式的关系。在这项横断面研究中,共检查了129名肥胖儿童(BMI大于或等于年龄和性别的第95百分位)。空腹采血测定血糖水平、血脂,包括总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、血清尿酸(SUA)和胰岛素水平。二维(2-D)经胸超声心动图确定左心室几何形态。对所有肥胖儿童进行24小时动态血压记录。采用线性回归分析探讨AIP(以TG / HDL-C比值的对数变换计算)和sABPI与左室心肌质量指数(LVMI)和相对壁厚(RWT)之间的关系。我们还使用性别作为潜在的影响调节因素,并计算了特定层的影响估计。我们证明年龄和AIP与RWT呈正相关(年龄:效应值= 0.83 (CI 0.22 - 1.45) p = 0.008;AI效应大小8.9 (CI 3.6 - 14.3);p = 0.01)。在以性别作为影响因子的亚组分析中,仅在男孩AIP中,AIP与RWT之间存在独立的正相关,p = 0.011的临界显著性:效应大小为9.5 (CI 2.3 - 16.7) p = 0.01。LVMI与性别和BMI显著相关(性别:效应值= 6.8 CI (2.6 - 11) p = 0.002;BMI z评分:效应值= 6.8 CI (3.2-10.4) p
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来源期刊
Pediatric Cardiology
Pediatric Cardiology 医学-小儿科
CiteScore
3.30
自引率
6.20%
发文量
258
审稿时长
12 months
期刊介绍: The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.
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