Deployment to bases with open burn pits and mortality of US Military Veterans.

IF 3.9 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Christian Hoover, Amal N Trivedi, Anila Bello, William J Culpepper, Joseph Gasper, Rachel Gaither, Lan Jiang, Christopher Rennix, Aaron Schneiderman, Gregory A Wellenius, Susan R Woskie, David A Savitz
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引用次数: 0

Abstract

Introduction: Five million US Veterans had possible exposure to open burn pits used for waste disposal through service in Iraq (2003-2011) and Afghanistan (2001-2014). Burn pits generate toxic exposures that may be associated with adverse health outcomes. We examined all-cause and cause-specific mortality in relation to deployment to bases with open burn pits.

Methods: We analysed a cohort of 474 634 Veterans who received some healthcare from the Veterans Health Administration, linked to Department of Defense deployment records to identify assignments to bases with burn pits. In multivariable logistic regression models, we assessed the association between duration of deployment to bases with burn pits and all-cause mortality and cause-specific mortality from the six most common causes among this population of Veterans.

Results: Duration of deployment to bases with burn pits was modestly related to all-cause mortality, with adjusted ORs of 1.07 (95% CI 0.99 to 1.15), 1.08 (95% CI 1.00 to 1.16) and 1.16 (95% CI 1.06 to 1.27) across tertiles, but not associated with mortality due to cancer, heart disease or chronic liver disease/cirrhosis. Positive associations were also found for unintentional injuries, suicide and stroke.

Discussion: These data are suggestive of an association between duration of deployment to bases with burn pits and overall mortality, but not from cancer or heart disease. Unexpected associations with injury and suicide call for a more detailed evaluation. Conclusions are restricted by the broad aggregations of causes of death, a limited number of deaths in this relatively young cohort and the lack of more detailed information on exposure to burn pits.

部署到有露天火坑和美国退伍军人死亡率的基地。
导读:在伊拉克(2003-2011年)和阿富汗(2001-2014年)服役期间,500万美国退伍军人可能接触过用于废物处理的露天焚烧坑。烧伤坑产生可能与不良健康结果相关的有毒暴露。我们检查了与部署到有露天烧伤坑的基地有关的全因死亡率和特定原因死亡率。方法:我们分析了474634名退伍军人,他们从退伍军人健康管理局获得了一些医疗保健,并与国防部的部署记录相关联,以确定在有烧伤坑的基地的任务。在多变量logistic回归模型中,我们评估了部署到有烧伤坑的基地的时间与退伍军人人群中六种最常见原因的全因死亡率和病因特异性死亡率之间的关系。结果:部署到有烧伤坑的基地的时间与全因死亡率有一定的相关性,调整后的or值为1.07 (95% CI 0.99至1.15)、1.08 (95% CI 1.00至1.16)和1.16 (95% CI 1.06至1.27),但与癌症、心脏病或慢性肝病/肝硬化导致的死亡率无关。在意外伤害、自杀和中风方面也发现了正相关。讨论:这些数据表明部署到有烧伤坑的基地的时间与总体死亡率之间存在关联,但与癌症或心脏病无关。与伤害和自杀的意外联系需要更详细的评估。由于死亡原因的广泛汇总,在这个相对年轻的队列中死亡人数有限,以及缺乏关于烧伤坑暴露的更详细信息,结论受到限制。
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来源期刊
Occupational and Environmental Medicine
Occupational and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
8.30
自引率
2.00%
发文量
98
审稿时长
2 months
期刊介绍: Occupational and Environmental Medicine is an international peer reviewed journal covering current developments in occupational and environmental health worldwide. Occupational and Environmental Medicine publishes high-quality research relating to the full range of chemical, physical, ergonomic, biological and psychosocial hazards in the workplace and to environmental contaminants and their health effects. The journal welcomes research aimed at improving the evidence-based practice of occupational and environmental research; including the development and application of novel biological and statistical techniques in addition to evaluation of interventions in controlling occupational and environmental risks.
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