{"title":"Benzaldehyde and azaphilone derivatives from the marine-derived fungus <i>Penicillium sclerotiorum</i> PSU-AMF89.","authors":"Praphatsorn Saetang, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj","doi":"10.1080/14786419.2024.2442101","DOIUrl":null,"url":null,"abstract":"<p><p>Two new compounds including one benzaldehyde (<b>1</b>) and one azaphilone (<b>2</b>) were isolated from the marine-derived fungus <i>Penicillium sclerotiorum</i> PSU-AMF89 together with nine known compounds (<b>3</b>-<b>11</b>). Their structures were determined by spectroscopic evidences. The absolute configuration of <b>2</b> was established by comparison of the ECD data with those of the previously reported data of compound <b>7</b> as well as the biosynthetic consideration. Compound <b>1</b> displayed potent cytotoxic activity against MCF-7 cells with an IC<sub>50</sub> value of 9 <i>µ</i>M, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds <b>3</b> and <b>8</b> were moderately active against <i>Cryptococcus neoformans</i> and methicillin-resistant <i>Staphylococcus aureus</i>, respectively, with equal MIC values of 64 <i>µ</i>g/mL. In addition, they were non-cytotoxic to noncancerous Vero cells.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2442101","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
Two new compounds including one benzaldehyde (1) and one azaphilone (2) were isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89 together with nine known compounds (3-11). Their structures were determined by spectroscopic evidences. The absolute configuration of 2 was established by comparison of the ECD data with those of the previously reported data of compound 7 as well as the biosynthetic consideration. Compound 1 displayed potent cytotoxic activity against MCF-7 cells with an IC50 value of 9 µM, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds 3 and 8 were moderately active against Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus, respectively, with equal MIC values of 64 µg/mL. In addition, they were non-cytotoxic to noncancerous Vero cells.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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