Trigeminal neuralgia within the disease course of MS: Diagnostic and therapeutic implications from a multicenter cohort.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2024-12-27 DOI:10.1177/13524585241309257

Sini M Laakso, Jiwon Oh, Fasna Raufdeen, Ashley Jones, Henri Reiskanen, Ken Feb, Elle Levit, Andrew J Solomon

引用次数: 0

Abstract

Trigeminal neuralgia (TN) is commonly associated with multiple sclerosis (MS). Whether TN should be considered a clinical relapse or evidence of active disease lacks consensus. TN was diagnosed in 0.9%-1.9% (n = 171) of people with multiple sclerosis (pwMS) at three international sites. In 9.9%, TN was their first potential demyelinating symptom. In 86%, TN onset occurred a median of 13-16 years after MS diagnosis. A clinical relapse occurred within 6 months of TN onset in 20% of pwMS. These data suggest TN onset should be evaluated as active disease and incorporated in diagnostic and therapeutic decisions in MS.

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多发性硬化症病程中的三叉神经痛：来自多中心队列的诊断和治疗意义。

三叉神经痛（TN）通常与多发性硬化症（MS）有关。TN是否应被视为临床复发或活动性疾病的证据缺乏共识。在三个国际研究中心，0.9%-1.9% （n = 171）的多发性硬化症（pwMS）患者被诊断为TN。9.9%的患者，TN是他们的第一个潜在脱髓鞘症状。86%的患者在MS诊断后13-16年发病。20%的pwMS患者在TN发病6个月内出现临床复发。这些数据表明，TN发病应作为活动性疾病进行评估，并纳入MS的诊断和治疗决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585