Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Masoud Lahouty, Manouchehr Fadaee, Dariush Shanehbandi, Tohid Kazemi
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引用次数: 0

Abstract

Colorectal cancer (CRC) ranks as the third most common cancer worldwide and remains a major cause of cancer-related deaths, necessitating the development of innovative therapeutic approaches beyond conventional treatment modalities. Conventional therapies, such as radiation, chemotherapy, and surgery, are hindered by challenges like imprecise targeting, substantial toxicity, and the development of resistance. Exosome-driven nano-immunotherapy has emerged as a groundbreaking approach that leverages the natural properties of exosomes-cell-derived vesicles known for their role in intercellular communication-to deliver therapeutic agents with high precision and specificity. This approach utilizes the natural ability of exosomes to serve as natural nanocarriers for various biomolecules, such as proteins, nucleic acids, and lipids, enabling precise drug delivery and immune modulation. Exosomes offer distinct advantages compared to traditional drug delivery systems, including their biocompatibility, capability to traverse biological barriers, and suitability for personalized medicine approaches. We evaluate the effectiveness of exosome-based therapies in comparison to traditional approaches, emphasizing their ability to achieve precise delivery, minimize systemic toxicity, and enhance treatment results. Despite their promise, several challenges remain, including the standardization of exosome isolation and production, optimization of cargo loading techniques, and ensuring safety and efficacy in clinical applications. By overcoming these obstacles and leveraging the distinctive characteristics of exosomes, exosome-driven nano-immunotherapy presents a promising avenue for more efficient therapeutic interventions.

外泌体驱动的纳米免疫疗法:革命性的结直肠癌治疗。
结直肠癌(CRC)是世界上第三大最常见的癌症,并且仍然是癌症相关死亡的主要原因,因此需要开发超越传统治疗方式的创新治疗方法。传统疗法,如放疗、化疗和手术,受到不精确靶向、严重毒性和耐药性发展等挑战的阻碍。外泌体驱动的纳米免疫疗法已经成为一种突破性的方法,它利用外泌体的自然特性-细胞衍生的囊泡,以其在细胞间通讯中的作用而闻名-以高精度和特异性提供治疗剂。这种方法利用外泌体作为各种生物分子(如蛋白质、核酸和脂质)的天然纳米载体的天然能力,实现精确的药物输送和免疫调节。与传统的药物传递系统相比,外泌体具有明显的优势,包括它们的生物相容性、穿越生物屏障的能力以及对个性化医疗方法的适用性。与传统方法相比,我们评估了基于外泌体的治疗方法的有效性,强调了它们实现精确递送、最小化全身毒性和提高治疗效果的能力。尽管前景看好,但仍存在一些挑战,包括外泌体分离和生产的标准化,货物装载技术的优化,以及确保临床应用的安全性和有效性。通过克服这些障碍并利用外泌体的独特特性,外泌体驱动的纳米免疫疗法为更有效的治疗干预提供了一条有希望的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Biology Reports
Molecular Biology Reports 生物-生化与分子生物学
CiteScore
5.00
自引率
0.00%
发文量
1048
审稿时长
5.6 months
期刊介绍: Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.
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