Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-11-29 DOI:10.3390/md22120536

Hanyang Peng, Yanbo Zeng, Rui Zhang, Li Yang, Fei Wu, Cuijuan Gai, Jingzhe Yuan, Wenjun Chang, Haofu Dai, Xiachang Wang

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Abstract

Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (1-5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6-10). The structures and absolute configuration for new compounds 1-5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.

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南海软珊瑚中的樟脑类二萜。

类Cembranoid二萜是软珊瑚的特征化合物，结构多样，活性显著，是药物先导化合物的重要来源。本文从软珊瑚Sarcophyton crassocaule中分离到5个新的类膜二萜，meijicrassolins A-E(1-5)，以及5个先前报道的化合物（6-10）。新化合物1-5的结构和绝对构型通过广泛的光谱分析、单晶x射线晶体学、量子力学核磁共振（QM-NMR）和时变密度泛函理论/电子圆二色性（TDDFT/ECD）计算得到。化合物3、4和9在脂多糖（LPS）刺激的RAW264.7细胞中显示适度抑制一氧化氮的生成。总的来说，我们的研究成果丰富了软珊瑚次生代谢物的文库，为后续相关化合物的研究和开发提供了更多的分子实体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.