Determinants of pregnancy outcomes in early-onset intrahepatic cholestasis of pregnancy.

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Perinatal Medicine Pub Date : 2024-12-27 DOI:10.1515/jpm-2024-0440

Xiufang Shao, Haiyan Tang, Yingling Xiu, Kunhai Ren, Mian Pan

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引用次数: 0

Abstract

Objectives: To analyze pregnancy outcomes and factors influencing early-onset intrahepatic cholestasis of pregnancy (ICP), offering insights to improve the management, diagnosis, and treatment of ICP during pregnancy.

Methods: We categorized 127 pregnant women with ICP into two groups based on a gestational age cutoff of 28 weeks. The analysis centered on biochemical markers, pregnancy complications, and outcomes to identify factors influencing early-onset ICP.

Results: We found that biochemical markers including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase, total bilirubin, direct bilirubin (DBIL), indirect bilirubin, and cholesterol were significantly lower in early-onset ICP compared to late-onset ICP. Importantly, premature birth rates were higher in the early-onset ICP group. Through univariate and multivariate logistic regression analyses of these biochemical markers, GGT and DBIL emerged as significant predictive factors (OR=0.84 and 0.54).

Conclusions: Early-onset ICP is characterized by its early onset, prolonged duration, and a higher incidence of premature births compared to late-onset ICP, leading to adverse perinatal outcomes. This research underscores the protective role of GGT and DBIL in early-onset ICP.

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妊娠早期肝内胆汁淤积症妊娠结局的决定因素。

目的：分析妊娠结局及影响妊娠早发型肝内胆汁淤积症（ICP）的因素，为改善妊娠期ICP的管理、诊断和治疗提供参考。方法：我们将127例ICP孕妇按胎龄28周分为两组。分析以生化指标、妊娠并发症和结局为中心，以确定影响早发型ICP的因素。结果：我们发现生化指标包括丙氨酸转氨酶、天冬氨酸转氨酶、γ -谷氨酰转移酶（GGT）、碱性磷酸酶、总胆红素、直接胆红素（DBIL）、间接胆红素和胆固醇在早发性ICP中明显低于晚发性ICP。重要的是，早发性ICP组的早产率更高。通过对这些生化指标的单因素和多因素logistic回归分析，GGT和DBIL是显著的预测因素（OR=0.84和0.54）。结论：与迟发性ICP相比，早发型ICP具有发病早、持续时间长、早产发生率高的特点，可导致不良的围产期结局。本研究强调了GGT和DBIL在早发型ICP中的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatal Medicine 医学-妇产科学

CiteScore

4.40

自引率

8.30%

发文量

183

审稿时长

4-8 weeks

期刊介绍： The Journal of Perinatal Medicine (JPM) is a truly international forum covering the entire field of perinatal medicine. It is an essential news source for all those obstetricians, neonatologists, perinatologists and allied health professionals who wish to keep abreast of progress in perinatal and related research. Ahead-of-print publishing ensures fastest possible knowledge transfer. The Journal provides statements on themes of topical interest as well as information and different views on controversial topics. It also informs about the academic, organisational and political aims and objectives of the World Association of Perinatal Medicine.