Impact of breastfeeding and formula feeding on immune cell populations and blood cell parameters: an observational study.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Thamer A Hamdan, Saleh Alkhateeb, Ghaleb Oriquat, Adeeb Alzoubi, Khaled Abdul-Aziz Ahmed
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引用次数: 0

Abstract

Objective: Breastfeeding is associated with improved health outcomes in infancy and throughout adulthood as breast milk encompasses diverse immune-active factors that affect the ontogeny of the immune system in breastfed (BF) infants. Nevertheless, the impact of infant feeding on the immune system is poorly understood, and a comprehensive understanding of immune system development in human infants is lacking. In this observational study, we addressed the effects of different infant feeding approaches on cell populations and parameters in the peripheral blood of infants to gain insight into the innate and adaptive arms of the immune system.

Methods: Using flowcytometric analysis, we performed complete blood counts and immunoprofiling of peripheral blood collected from BF and formula-fed (FF) infants at different ages.

Results: Our results showed that the blood of BF infants had a higher frequency of leukocytes and erythrocytes in early infancy. The hemoglobin concentration was enhanced in BF infants. However, the platelet count was comparable regardless of feeding regimen.

Conclusions: We observed immunophenotypic differences between the two populations of infants, mirrored by improved frequency of innate and adaptive immune cells in BF infants.

母乳喂养和配方奶喂养对免疫细胞群和血细胞参数的影响:一项观察性研究。
目的:母乳喂养与婴儿期和整个成年期的健康状况改善有关,因为母乳中含有多种免疫活性因子,这些因子会影响母乳喂养婴儿免疫系统的个体发育。然而,人们对婴儿喂养对免疫系统的影响知之甚少,对人类婴儿免疫系统的发育缺乏全面的了解。在这项观察性研究中,我们研究了不同的婴儿喂养方式对婴儿外周血中细胞群和参数的影响,以深入了解免疫系统的先天和适应性臂。方法:采用流式细胞术分析,对不同年龄的BF和FF婴儿的外周血进行全血细胞计数和免疫谱分析。结果:我们的研究结果表明,BF婴儿在婴儿期早期血液中白细胞和红细胞的频率较高。BF婴儿血红蛋白浓度升高。然而,无论喂养方案如何,血小板计数都具有可比性。结论:我们观察到两组婴儿的免疫表型差异,反映在先天性和适应性免疫细胞在BF婴儿中的频率提高。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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