Incorporating Physical Activity in a New Two-Oscillator Model of Circadian Activity in Nocturnal and Diurnal Mammals.

Abstract

In both diurnal and nocturnal species, the neurons in the suprachiasmatic nucleus (SCN) generate a daily pattern in which the impulse frequency peaks at midday and is lowest during the night. This pattern, common to both day-active and night-active species, has led to the long-standing notion that their functional difference relies merely on a sign reversal in SCN output. However, recent evidence shows that the response of the SCN to the animal's physical activity is opposite in nocturnal and diurnal animals. This finding suggests the presence of additional differences in the circadian system between nocturnal and diurnal species. We therefore attempted to identify these differences in neuronal network organization using the A-B two-oscillator model, which is comprised of Poincaré like oscillators. Based on this model, we infer that in diurnal animals the feedback from physical activity acts on neuronal subpopulations in the SCN that do not receive light input; in contrast, in nocturnal animals, physical activity acts on light-receptive neurons in the SCN in order to produce high-amplitude circadian rhythms.