The causal relationship between 233 metabolites and coronary atherosclerosis: a Mendelian randomization study.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2024-12-12 eCollection Date: 2024-01-01 DOI:10.3389/fcvm.2024.1439699

Hongwei Zhang, Xiaoyu Zheng, Zian Yan, Lijun Guo, Yuan Zheng, Dawu Zhang, Xiaochang Ma

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引用次数: 0

Abstract

Objective: To investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.

Methods: Five different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods.

Results: The analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, including: Total fatty acids (OR = 1.40, 95% CI: 1.28-1.53, P < 0.001), Saturated fatty acids (OR = 1.44, 95% CI: 1.30-1.60, P < 0.001), Serum total triglyceride levels (OR = 1.33, 95% CI: 1.22-1.46, P < 0.001), Conjugated linoleic acid (OR = 1.16, 95% CI: 1.04-1.30, P = 0.007). Conversely, certain metabolites were found to reduce the occurrence of coronary atherosclerosis, such as: Cholesteryl esters to total lipids ratio in medium HDL (OR = 0.73, 95% CI: 0.67-0.78, P < 0.001), Cholesteryl esters to total lipids ratio in large HDL (OR = 0.64, 95% CI: 0.58-0.71, P < 0.001), Total cholesterol to total lipids ratio in medium HDL (OR = 0.71, 95% CI: 0.65-0.77, P < 0.001).

Conclusion: There is a close relationship between metabolites and the occurrence of coronary atherosclerosis. This study conducted Mendelian randomization analysis on the causal relationship between 233 metabolites and coronary atherosclerosis, providing potential new insights for the treatment of this disease.

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233种代谢物与冠状动脉粥样硬化之间的因果关系：孟德尔随机研究。

目的：通过孟德尔随机化分析，探讨233种新报道的代谢物与冠状动脉粥样硬化的因果关系。方法：采用5种不同的方法对233种代谢物与冠状动脉粥样硬化进行孟德尔随机化分析，以方差逆加权为主要结果，其他方法为辅。结果：分析发现某些代谢物增加冠状动脉粥样硬化的易感性风险，包括：总脂肪酸（OR = 1.40, 95% CI: 1.28-1.53, P P P P = 0.007）。相反，发现某些代谢物可以减少冠状动脉粥样硬化的发生，如：中等HDL中胆固醇酯与总脂的比值（OR = 0.73, 95% CI: 0.67-0.78, P P P P）结论：代谢物与冠状动脉粥样硬化的发生有密切关系。本研究对233种代谢物与冠状动脉粥样硬化的因果关系进行了孟德尔随机化分析，为该疾病的治疗提供了潜在的新见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.