Gabriele Lo Buglio, Marta Mirabella, Laura Muzi, Tommaso Boldrini, Erika Cerasti, Jone Bjornestad, Flavia Fiorentino, Andrea Polari, Eleonora Riccioli, Michele Angelo Rugo, Marco Solmi, Vittorio Lingiardi, Annalisa Tanzilli
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引用次数: 0
Abstract
Background: Eating disorders (EDs) are among the least studied mental disorders in individuals at clinical high risk for psychosis (CHR-P). The primary aim (a) of this systematic review and meta-analysis was to identify factors predicting ED diagnoses in CHR-P individuals. The secondary aim (b) was providing a comprehensive clinical description of individuals with both CHR-P and EDs/ED-related symptoms.
Methods: Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review and meta-analysis, searching PubMed/(EBSCO)PsycINFO/Web of Science for studies published between 01/01/2018 and 30/05/2023, including individuals with CHR-P and EDs/ED symptoms (PROSPERO CRD42023488792). Quality assessment was performed using the Newcastle-Ottawa Scale (NOS). We performed a meta-regression model on the proportion of EDs in CHR-P individuals (primary aim) and conducted a narrative synthesis (secondary aim).
Results: We included 26 articles, reporting on 2,060 and 589 subjects for study aim (a) and (b), respectively (mean NOS score = 6.38). The prevalence of EDs in CHR-P individuals was 0.05 (95% CI 0.3-0.8). No factor had a significant effect on the proportion of EDs in CHR-P individuals. This result is limited by the inability to include ED-related symptoms and antipsychotic prescriptions in the meta-regression model, due to an insufficient number of studies reporting on these variables. The narrative synthesis offers a characterization of individuals with both CHR-P and ED/ED-related symptoms; however, the limited number of included studies is insufficient to support definitive conclusions.
Conclusions: No significant predictor of EDs was found in CHR-P individuals. Transdiagnostic, prospective cohort studies are warranted to examine long-term outcomes in individuals with both CHR-P and EDs, beyond diagnostic silos.
Level of evidence: I. Systematic review and meta-analysis.
期刊介绍：
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.
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