Diabetes mellitus in patients with myasthenia gravis: a systematic review and meta-analysis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-12-27 DOI:10.1007/s12020-024-04143-1

Tianrui Shao, Jing Lu, Hailan Kang, Yibin Zhang, Tianye Lan, Jian Wang

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引用次数: 0

Abstract

Objectives: With the prolongation of life expectancy in patients with myasthenia gravis, the number of comorbidities is increasing. Diabetes mellitus is one of the main comorbidities faced by patients with myasthenia gravis. However, there is not enough epidemiological information on diabetes mellitus. Given these limitations, the purpose of this study was to review the prevalence of diabetes mellitus in patients with myasthenia gravis and whether the myasthenia gravis is associated with an increased risk of gestational diabetes mellitus.

Methods: PubMed, Embase, and Web of Science were searched for articles published prior to February 2024. Endnote 21 software was used to manage all relevant records. Review Manager version 5.4 and Stata version 18.0 software were used for the statistical analysis. Funnel plots and Egger's test were used to assess publication bias.

Results: Twenty-four articles met the inclusion criteria and were included in the study. Among 23,516 myasthenia gravis patients, the prevalence of diabetes mellitus was 17% (95% CI 12~22%). In addition, the meta-analysis of the two studies showed that myasthenia gravis was significantly associated with an increased risk of gestational diabetes mellitus (OR = 1.56, 95% CI 1.26~1.93, p < 0.01).

Conclusions: Among the comorbidities of myasthenia gravis patients, diabetes mellitus is common, and the risk of gestational diabetes mellitus is increased in myasthenia gravis patients. These findings remind us that diabetes mellitus seems to be an important issue in the clinical management of myasthenia gravis patients and requires more attention.

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重症肌无力患者的糖尿病：系统回顾和荟萃分析。

目的：随着重症肌无力患者预期寿命的延长，其合并症的数量也在不断增加。糖尿病是重症肌无力患者面临的主要合并症之一。然而，关于糖尿病的流行病学资料还不够。鉴于这些局限性，本研究的目的是回顾重症肌无力患者糖尿病的患病率，以及重症肌无力是否与妊娠期糖尿病的风险增加有关。方法：检索2024年2月前发表的PubMed、Embase和Web of Science论文。使用Endnote 21软件对所有相关记录进行管理。采用Review Manager version 5.4和Stata version 18.0软件进行统计分析。采用漏斗图和Egger检验评估发表偏倚。结果：24篇符合纳入标准的文献被纳入研究。23516例重症肌无力患者中，糖尿病患病率为17% （95% CI 12~22%）。此外，两项研究的荟萃分析显示，重症肌无力与妊娠期糖尿病风险增加显著相关（OR = 1.56, 95% CI 1.26~1.93, p）。结论：在重症肌无力患者的合并症中，糖尿病较为常见，重症肌无力患者妊娠期糖尿病风险增加。这些发现提醒我们，糖尿病似乎是重症肌无力患者临床管理的一个重要问题，需要更多的关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.